Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state

Structure

electron microscopy · 2 distinct chains.

Ligands and binding sites

• HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, C
• NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, C
• FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, C
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 14 copies · chains B, C, D, A
• MAN · alpha-D-mannopyranose · sugar · 14 copies · chains B, C, A, D
• BMA · beta-D-mannopyranose · sugar · 2 copies · chains C, A
• NA · Sodium ion · metal · 4 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7D3E · Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state · the same entry in another collection · chain D against D, TM-score 1.00
• Q1HG43 · AlphaFold monomer V2.0 prediction for dual oxidase maturation factor 1 (Q1HG43) · a predicted model of the same protein · chain B against A, TM-score 1.00
• Q9NRD9 · AlphaFold monomer V2.0 prediction for dual oxidase 1 (Q9NRD9) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NRD9
• Every structure of UniProt Q1HG43
• Elsewhere: RCSB PDB 7D3E · PDBe 7D3E · UniProt Q9NRD9 · UniProt Q1HG43