UniProt Q9NRD9
Dual oxidase 1 (Q9NRD9)
Dual oxidase 1 (UniProt Q9NRD9), EC 1.11.1.-, 1.6.3.1: 4 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NRD9
- Protein
- Dual oxidase 1
- EC
- 1.11.1.-, 1.6.3.1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 40 · 2 records with a druggable one
Structures
5 records of Q9NRD9 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7D3E | Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state | electron microscopy | A, C | NAG, BMA, MAN, HEM, NDP, FAD | 20 (best 0.87) |
| 7D3E | Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state | electron microscopy | A, C | NAG, BMA, MAN, HEM, NDP, FAD | — |
| 7D3F | Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state | electron microscopy | A, C | NAG, BMA, MAN, HEM, NDP, FAD | 20 (best 0.87) |
| 7D3F | Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state | electron microscopy | A, C | NAG, BMA, MAN, HEM, NDP, FAD | — |
| Q9NRD9 | AlphaFold monomer V2.0 prediction for dual oxidase 1 (Q9NRD9) | predicted | A | — | — |
Ligands
- BMA · beta-D-mannopyranose · in 4 records
- FAD · Flavin-adenine dinucleotide · in 4 records
- HEM · Protoporphyrin IX containing Fe · in 4 records
- MAN · alpha-D-mannopyranose · in 4 records
- NA · Sodium ion · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 4 records
- CA · Calcium ion · in 2 records
Experiment against prediction
- 7D3F chain A against the predicted model Q9NRD9: TM-score 0.99, RMSD 1.32 Å
- 7D3F chain A against the predicted model Q9NRD9: TM-score 0.99, RMSD 1.32 Å
- 7D3F chain C against the predicted model Q9NRD9: TM-score 0.99, RMSD 1.32 Å
- 7D3F chain C against the predicted model Q9NRD9: TM-score 0.99, RMSD 1.32 Å
- 7D3E chain A against the predicted model Q9NRD9: TM-score 0.94, RMSD 2.27 Å
- 7D3E chain A against the predicted model Q9NRD9: TM-score 0.94, RMSD 2.27 Å
- 7D3E chain C against the predicted model Q9NRD9: TM-score 0.94, RMSD 2.27 Å
- 7D3E chain C against the predicted model Q9NRD9: TM-score 0.94, RMSD 2.27 Å
Elsewhere
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