MolNFT v1 · #170371 · protein + DNA
Structure of human cgas (K394E) bound to the nucleosome (focused refinement of cgas-ncp subcomplex)
6Y5E: “Structure of human cgas (K394E) bound to the nucleosome (focused refinement of cgas-ncp subcomplex)”. Electron microscopy, 2 ligands (PTD, ZN). MolNFT v1 #170371 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Y5E
- Type
- protein + DNA
- Length
- 1,426 residues
- Chains
- 11
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q71DI3, P62805, Q16777, O60814, Q8N884
- Ligands
- PTD, ZN
Structure
electron microscopy · 10 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | — | protein | 96 | — | Q71DI3 |
| B | — | protein | 81 | — | P62805 |
| C | — | protein | 107 | — | Q16777 |
| D | — | protein | 93 | — | O60814 |
| F | — | protein | 83 | — | P62805 |
| G | — | protein | 108 | — | Q16777 |
| H | — | protein | 94 | — | O60814 |
| I | — | dna | 153 | — | — |
| J | — | dna | 153 | — | — |
| K | — | protein | 362 | — | Q8N884 |
Ligands and binding sites
- PTD · Pentanedial · ligand · 8 copies · chains A, B, C, G, D, E, F, H, K
- ZN · Zinc ion · metal · chains K
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6Y5E · Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP… · the same entry in another collection · chain K against K, TM-score 1.00
- Q71DI3 · AlphaFold monomer V2.0 prediction for histone H3.2 (Q71DI3) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71DI3
- Every structure of UniProt P62805
- Every structure of UniProt Q16777
- Every structure of UniProt O60814
- Every structure of UniProt Q8N884
- Elsewhere: RCSB PDB 6Y5E · PDBe 6Y5E · UniProt Q71DI3 · UniProt P62805 · UniProt Q16777 · UniProt O60814 · UniProt Q8N884
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