UniProt Q16777
Histone H2A type 2-C (Q16777)
Histone H2A type 2-C (UniProt Q16777): 13 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 169 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16777
- Protein
- Histone H2A type 2-C
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 169 · 12 records with a druggable one
Structures
14 records of Q16777 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6Y5E | Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex) | electron microscopy | C, G | PTD | 14 (best 0.82) |
| 6Y5E | Structure of human cgas (K394E) bound to the nucleosome (focused refinement of cgas-ncp subcomplex) | electron microscopy | C, G | PTD | — |
| 7U0G | structure of LIN28b nucleosome bound 3 OCT4 | electron microscopy | C, G | — | 13 (best 0.80) |
| 7U0I | Structure of LIN28b nucleosome bound 2 OCT4 | electron microscopy | C, G | — | 16 (best 0.81) |
| 7U0J | Structure of 162bp LIN28b nucleosome | electron microscopy | C, G | — | 13 (best 0.78) |
| 8DK5 | Structure of 187bp LIN28b nucleosome with site 0 mutation | electron microscopy | C, G | — | 15 (best 0.82) |
| 8EVG | 162bp CX3CR1 nucleosome (further classified with better nucleosome end) | electron microscopy | C, G | — | 16 (best 0.75) |
| 8EVH | CX3CR1 nucleosome and wild type PU.1 complex | electron microscopy | C, G | — | 13 (best 0.78) |
| 8EVI | CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations | electron microscopy | C, G | — | 16 (best 0.76) |
| 8EVJ | CX3CR1 nucleosome bound PU.1 and C/EBPa | electron microscopy | C, G | — | 15 (best 0.80) |
| 8SPS | High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b | electron microscopy | C, G | — | 12 (best 0.82) |
| 8SPU | Structure of ESRRB nucleosome bound OCT4 at site c | electron microscopy | G, C | — | 12 (best 0.82) |
| 8SYP | Genomic CX3CR1 nucleosome | electron microscopy | C, G | — | 14 (best 0.78) |
| Q16777 | AlphaFold monomer V2.0 prediction for histone H2A type 2-C (Q16777) | predicted | A | — | — |
Ligands
- PTD · Pentanedial · in 2 records
Experiment against prediction
- 7U0J chain G against the predicted model Q16777: TM-score 0.95, RMSD 0.94 Å
- 8SPS chain G against the predicted model Q16777: TM-score 0.95, RMSD 0.94 Å
- 8SPU chain C against the predicted model Q16777: TM-score 0.95, RMSD 0.94 Å
- 8DK5 chain G against the predicted model Q16777: TM-score 0.95, RMSD 0.94 Å
- 7U0I chain G against the predicted model Q16777: TM-score 0.95, RMSD 0.98 Å
- 8EVG chain C against the predicted model Q16777: TM-score 0.95, RMSD 1.00 Å
- 8SYP chain G against the predicted model Q16777: TM-score 0.95, RMSD 1.19 Å
- 8EVG chain G against the predicted model Q16777: TM-score 0.95, RMSD 1.02 Å
- 8SYP chain C against the predicted model Q16777: TM-score 0.95, RMSD 1.32 Å
- 7U0J chain C against the predicted model Q16777: TM-score 0.95, RMSD 1.06 Å
Elsewhere
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