MolNFT v1 · #166673 · protein
Structure of the human mitochondrial desulfurase complex NFS1- ISCU2(M140I)-ISD11 with E.COLI ACP1 at 1.57 a resolution showing flexibility of N terminal end of ISCU2
6UXE: “Structure of the human mitochondrial desulfurase complex NFS1- ISCU2(M140I)-ISD11 with E.COLI ACP1 at 1.57 a…”. X-ray diffraction, 4 ligands (PLP, P15, EDT). MolNFT v1 #166673 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6UXE
- Type
- protein
- Length
- 681 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9Y697, Q9HD34, B7MJ81, Q9H1K1
- Ligands
- PLP, P15, EDT, 8Q1
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 395 | — | Q9Y697 |
| B | — | protein | 85 | — | Q9HD34 |
| C | — | protein | 75 | — | B7MJ81 |
| D | — | protein | 126 | — | Q9H1K1 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
- P15 · 2,5,8,11,14,17-hexaoxanonadecan-19-ol · ligand · chains A, D
- EDT · {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid · ligand · chains B
- 8Q1 · S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate · ligand · chains A, B, C
- EDO · 1,2-ethanediol · additive · 50 copies · chains A, D, B, C
- PEG · Di(hydroxyethyl)ether · additive · 11 copies · chains A, B, D, C
- GOL · Glycerol · additive · 6 copies · chains A, B, D
- PGE · Triethylene glycol · additive · 3 copies · chains A
- PG4 · Tetraethylene glycol · additive · 2 copies · chains A
- DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains B, C
- 1PE · Pentaethylene glycol · additive · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6UXE · Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9Y697 · AlphaFold monomer V2.0 prediction for cysteine desulfurase, mitochondrial (Q9Y697) · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q9H1K1 · AlphaFold monomer V2.0 prediction for iron-sulfur cluster assembly enzyme iscu… · a predicted model of the same protein · chain D against A, TM-score 0.98
- B7MJ81 · AlphaFold monomer V2.0 prediction for acyl carrier protein (B7MJ81) · a predicted model of the same protein · chain C against A, TM-score 0.97
- Q9HD34 · AlphaFold monomer V2.0 prediction for lyr motif-containing protein 4 (Q9HD34) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y697
- Every structure of UniProt Q9HD34
- Every structure of UniProt B7MJ81
- Every structure of UniProt Q9H1K1
- Elsewhere: RCSB PDB 6UXE · PDBe 6UXE · UniProt Q9Y697 · UniProt Q9HD34 · UniProt B7MJ81 · UniProt Q9H1K1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.