UniProt Q9H1K1
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (Q9H1K1)
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (UniProt Q9H1K1): 26 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9H1K1
- Protein
- Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 54 · 7 records with a druggable one
Structures
27 records of Q9H1K1 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KZ5 | Architecture of the human mitochondrial iron-sulfur cluster assembly machinery: the complex formed… | electron microscopy | a, b, c, d, e, f, g, h, i, j, k, l | — | — |
| 5WKP | Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and… | x-ray diffraction | D, H | — | 5 (best 0.77) |
| 5WKP | Crystal structure of the human mitochondrial cysteine desulfurase in complex with ISD11 and… | x-ray diffraction | D, H | — | — |
| 5WLW | Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within… | x-ray diffraction | D, H | ZN | 4 (best 0.69) |
| 5WLW | Crystal structure of the human mitochondrial cysteine desulfurase with active cysteine loop within… | x-ray diffraction | D, H | ZN | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | D, H | ZN | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | D, H | ZN | — |
| 6UXE | Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with E.coli ACP1… | x-ray diffraction | D | P15 | — |
| 6UXE | Structure of the human mitochondrial desulfurase complex NFS1- ISCU2(M140I)-ISD11 with E.COLI ACP1… | x-ray diffraction | D | P15 | — |
| 6W1D | Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution… | x-ray diffraction | D | P15 | — |
| 6W1D | Structure of human mitochondrial complex NFS1-ISCU2 (wt)-ISD11 with E.COLI ACP1 at 1.8 a resolution… | x-ray diffraction | D | P15 | — |
| 6WI2 | Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution… | x-ray diffraction | D | — | 2 (best 0.44) |
| 6WI2 | Structure of human mitochondrial complex NFS1-ISCU2-ISD11 with E.COLI ACP1 at 1.95 a resolution… | x-ray diffraction | D | — | — |
| 6WIH | N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal… | x-ray diffraction | D | P15 | 2 (best 0.46) |
| 6WIH | N-terminal mutation of ISCU2 (L35H36) traps NFS1 cys loop in the active site of ISCU2 without metal… | x-ray diffraction | D | P15 | — |
| 7RTK | Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution | x-ray diffraction | D | P15 | — |
| 7RTK | Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 a resolution | x-ray diffraction | D | — | — |
| 8PK8 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | D | FE2 | 4 (best 0.73) |
| 8PK9 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | D | FE2 | 2 (best 0.45) |
| 8PKA | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | D | FE2 | 3 (best 0.37) |
| 8RMC | Structure of the FDX2-bound core ISC complex (proximal conformation) | electron microscopy | D, H | FE2 | 7 (best 0.87) |
| 8RMD | Structure of the FDX2-bound core ISC complex (distal conformation) | electron microscopy | D, H | FE2 | 5 (best 0.50) |
| 8RME | Structure of the core ISC complex under turnover conditions (frataxin-bound) | electron microscopy | D, H | FE2 | 5 (best 0.80) |
| 8RMF | Structure of the core ISC complex under turnover conditions (FDX2-bound in proximal conformation) | electron microscopy | D, H | FE2 | 7 (best 0.87) |
| 8RMG | Structure of the core ISC complex under turnover conditions (FDX2-bound in distal conformation) | electron microscopy | D, H | FE2 | 7 (best 0.80) |
| 8TVT | Structure of human Cysteine desulfurase Nfs1 with L-propargylglycine bound to active site PLP in… | x-ray diffraction | D | P15 | 1 (best 0.39) |
| Q9H1K1 | AlphaFold monomer V2.0 prediction for iron-sulfur cluster assembly enzyme iscu, mitochondrial… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8PK9 chain D against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.44 Å
- 8PK8 chain D against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.45 Å
- 5WKP chain H against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.49 Å
- 5WKP chain H against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.49 Å
- 7RTK chain D against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.50 Å
- 7RTK chain D against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.50 Å
- 8RME chain D against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.51 Å
- 8RMG chain D against the predicted model Q9H1K1: TM-score 0.99, RMSD 0.52 Å
- 5WKP chain D against the predicted model Q9H1K1: TM-score 0.98, RMSD 0.53 Å
- 5WKP chain D against the predicted model Q9H1K1: TM-score 0.98, RMSD 0.53 Å
Elsewhere
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