UniProt Q9HD34
LYR motif-containing protein 4 (Q9HD34)
LYR motif-containing protein 4 (UniProt Q9HD34): 17 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9HD34
- Protein
- LYR motif-containing protein 4
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 37 · 5 records with a druggable one
Structures
18 records of Q9HD34 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5USR | Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms | x-ray diffraction | B, D, F, H | 8Q1 | 13 (best 0.82) |
| 5USR | Crystal structure of human NFS1-ISD11 in complex with E. COLI acyl- carrier protein at 3.09… | x-ray diffraction | B, D, F, H | 8Q1 | — |
| 5WGB | Crystal structure of the human mitochondrial cysteine desulfurase in complex with ISD11 and E. COLI… | x-ray diffraction | B | 8Q1 | — |
| 5WKP | Crystal structure of the human mitochondrial cysteine desulfurase in complex with ISD11 and… | x-ray diffraction | B, F | 8Q1 | — |
| 5WLW | Crystal structure of the human mitochondrial cysteine desulfurase with active cysteine loop within… | x-ray diffraction | B, F | 8Q1 | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | B, F | 8Q1 | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | B, F | 8Q1 | — |
| 6ODD | Crystal structure of the human complex ACP-ISD11 | x-ray diffraction | B | 8Q1 | 2 (best 0.63) |
| 6ODD | Crystal structure of the human complex acp-ISD11 | x-ray diffraction | B | 8Q1 | — |
| 6UXE | Structure of the human mitochondrial desulfurase complex NFS1- ISCU2(M140I)-ISD11 with E.COLI ACP1… | x-ray diffraction | B | EDT, 8Q1 | — |
| 6W1D | Structure of human mitochondrial complex NFS1-ISCU2 (wt)-ISD11 with E.COLI ACP1 at 1.8 a resolution… | x-ray diffraction | B | EDT, 8Q1 | — |
| 6WI2 | Structure of human mitochondrial complex NFS1-ISCU2-ISD11 with E.COLI ACP1 at 1.95 a resolution… | x-ray diffraction | B | EDT, 8Q1 | — |
| 6WIH | N-terminal mutation of ISCU2 (L35H36) traps NFS1 cys loop in the active site of ISCU2 without metal… | x-ray diffraction | B | EDT, 8Q1 | — |
| 7RTK | Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 a resolution | x-ray diffraction | B | EDT, 8Q1 | — |
| 8PK8 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | B | 8Q1 | 4 (best 0.74) |
| 8RMD | Structure of the FDX2-bound core ISC complex (distal conformation) | electron microscopy | B, F | 8Q1 | 8 (best 0.78) |
| 8RMG | Structure of the core ISC complex under turnover conditions (FDX2-bound in distal conformation) | electron microscopy | B, F | 8Q1 | 10 (best 0.74) |
| Q9HD34 | AlphaFold monomer V2.0 prediction for lyr motif-containing protein 4 (Q9HD34) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8PK8 chain B against the predicted model Q9HD34: TM-score 0.99, RMSD 0.31 Å
- 8RMD chain B against the predicted model Q9HD34: TM-score 0.99, RMSD 0.33 Å
- 8RMG chain B against the predicted model Q9HD34: TM-score 0.99, RMSD 0.33 Å
- 8RMD chain F against the predicted model Q9HD34: TM-score 0.99, RMSD 0.36 Å
- 5WKP chain B against the predicted model Q9HD34: TM-score 0.99, RMSD 0.36 Å
- 8RMG chain F against the predicted model Q9HD34: TM-score 0.99, RMSD 0.39 Å
- 5WKP chain F against the predicted model Q9HD34: TM-score 0.99, RMSD 0.41 Å
- 5WLW chain B against the predicted model Q9HD34: TM-score 0.98, RMSD 0.44 Å
- 5WLW chain F against the predicted model Q9HD34: TM-score 0.98, RMSD 0.46 Å
- 6WI2 chain B against the predicted model Q9HD34: TM-score 0.98, RMSD 0.78 Å
Elsewhere
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