UniProt Q9Y697
Cysteine desulfurase, mitochondrial (Q9Y697)
Cysteine desulfurase, mitochondrial (UniProt Q9Y697), EC 2.8.1.7: 28 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 162 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9Y697
- Protein
- Cysteine desulfurase, mitochondrial
- EC
- 2.8.1.7
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 162 · 16 records with a druggable one
Structures
29 records of Q9Y697 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KZ5 | Architecture of the human mitochondrial iron-sulfur cluster assembly machinery: the complex formed… | electron microscopy | 1, 2, 3, 4, M, N, O, P, Q, R, S, T | — | — |
| 5USR | Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms | x-ray diffraction | A, C, E, G | 8Q1 | 14 (best 0.82) |
| 5USR | Crystal structure of human NFS1-ISD11 in complex with E. COLI acyl- carrier protein at 3.09… | x-ray diffraction | A, C, E, G | 8Q1 | — |
| 5WGB | Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli… | x-ray diffraction | A | PLP, 8Q1 | 6 (best 0.72) |
| 5WGB | Crystal structure of the human mitochondrial cysteine desulfurase in complex with ISD11 and E. COLI… | x-ray diffraction | A | PLP, 8Q1 | — |
| 5WKP | Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and… | x-ray diffraction | A, E | PLP, 8Q1 | 10 (best 0.77) |
| 5WKP | Crystal structure of the human mitochondrial cysteine desulfurase in complex with ISD11 and… | x-ray diffraction | A, E | PLP | — |
| 5WLW | Crystal structure of the human mitochondrial cysteine desulfurase with active cysteine loop within… | x-ray diffraction | A, E | PLP, ZN | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | A, E | PLP, 8Q1 | — |
| 6NZU | Structure of the human frataxin-bound iron-sulfur cluster assembly complex | electron microscopy | A, E | PLP, 8Q1 | — |
| 6UXE | Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with E.coli ACP1… | x-ray diffraction | A | PLP, P15, 8Q1 | 4 (best 0.74) |
| 6UXE | Structure of the human mitochondrial desulfurase complex NFS1- ISCU2(M140I)-ISD11 with E.COLI ACP1… | x-ray diffraction | A | PLP, P15, 8Q1 | — |
| 6W1D | Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution… | x-ray diffraction | A | PLP, P15, 8Q1 | 3 (best 0.73) |
| 6W1D | Structure of human mitochondrial complex NFS1-ISCU2 (wt)-ISD11 with E.COLI ACP1 at 1.8 a resolution… | x-ray diffraction | A | PLP, P15, 8Q1 | — |
| 6WI2 | Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution… | x-ray diffraction | A | PLP, ETE, EDT, 8Q1 | 6 (best 0.75) |
| 6WI2 | Structure of human mitochondrial complex NFS1-ISCU2-ISD11 with E.COLI ACP1 at 1.95 a resolution… | x-ray diffraction | A | PLP, ETE, EDT, 8Q1 | — |
| 6WIH | N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal… | x-ray diffraction | A | PLP, P15, EDT, 8Q1 | 6 (best 0.73) |
| 6WIH | N-terminal mutation of ISCU2 (L35H36) traps NFS1 cys loop in the active site of ISCU2 without metal… | x-ray diffraction | A | PLP, P15, EDT | — |
| 7RTK | Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution | x-ray diffraction | A | PLP, P15, 8Q1 | 3 (best 0.73) |
| 7RTK | Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 a resolution | x-ray diffraction | A | PLP, P15, 8Q1 | — |
| 8PK8 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | A | PLP, 8Q1 | 8 (best 0.74) |
| 8PK9 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | A | PLP, 8Q1, FE2 | 7 (best 0.74) |
| 8PKA | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | A | PLP, 8Q1, FE2 | 9 (best 0.74) |
| 8RMC | Structure of the FDX2-bound core ISC complex (proximal conformation) | electron microscopy | A, E | FE2, 8Q1 | 16 (best 0.87) |
| 8RMD | Structure of the FDX2-bound core ISC complex (distal conformation) | electron microscopy | A, E | 8Q1, FE2 | 15 (best 0.80) |
| 8RME | Structure of the core ISC complex under turnover conditions (frataxin-bound) | electron microscopy | A, E | FE2, 8Q1 | 18 (best 0.80) |
| 8RMF | Structure of the core ISC complex under turnover conditions (FDX2-bound in proximal conformation) | electron microscopy | A, E | 8Q1, FE2 | 17 (best 0.87) |
| 8RMG | Structure of the core ISC complex under turnover conditions (FDX2-bound in distal conformation) | electron microscopy | A, E | 8Q1, FE2 | 16 (best 0.80) |
| Q9Y697 | AlphaFold monomer V2.0 prediction for cysteine desulfurase, mitochondrial (Q9Y697) | predicted | A | — | 4 (best 0.43) |
Ligands
- 8Q1 · S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate · in 24 records
- PLP · Pyridoxal-5'-phosphate · in 20 records
- P15 · 2,5,8,11,14,17-hexaoxanonadecan-19-ol · in 8 records
- FE2 · Fe (II) ion · in 7 records
- EDT · {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid · in 4 records
- ETE · 2-{2-[2-2-(methoxy-ethoxy)-ethoxy]-ethoxy}-ethanol · in 2 records
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 7RTK chain A against the predicted model Q9Y697: TM-score 1.00, RMSD 0.49 Å
- 7RTK chain A against the predicted model Q9Y697: TM-score 1.00, RMSD 0.49 Å
- 6W1D chain A against the predicted model Q9Y697: TM-score 1.00, RMSD 0.51 Å
- 6W1D chain A against the predicted model Q9Y697: TM-score 1.00, RMSD 0.51 Å
- 6UXE chain A against the predicted model Q9Y697: TM-score 1.00, RMSD 0.51 Å
- 6UXE chain A against the predicted model Q9Y697: TM-score 1.00, RMSD 0.51 Å
- 5WKP chain A against the predicted model Q9Y697: TM-score 0.99, RMSD 0.61 Å
- 5WKP chain A against the predicted model Q9Y697: TM-score 0.99, RMSD 0.61 Å
- 5WKP chain E against the predicted model Q9Y697: TM-score 0.99, RMSD 0.59 Å
- 5WKP chain E against the predicted model Q9Y697: TM-score 0.99, RMSD 0.59 Å
Elsewhere
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