MolNFT v1 · #160079 · protein
PAC1 GPCR receptor complex
6P9Y · Guanine nucleotide-binding protein G(S) subunit alpha…: “PAC1 GPCR receptor complex”. Electron microscopy, 10 pockets (best druggability 0.81). MolNFT v1 #160079 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6P9Y
- Type
- protein
- Length
- 998 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P18509, P41586
- Pockets
- 10 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 194 | 44% helix, 18% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 43% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 55 | 44% helix, 0% strand | P59768 |
| N | Nanobody 35 | protein | 126 | 7% helix, 41% strand | — |
| P | Pituitary adenylate cyclase-activating polypeptide | protein | 27 | 89% helix, 0% strand | P18509 |
| R | Pituitary adenylate cyclase-activating polypeptide type I receptor | protein | 258 | 74% helix, 0% strand | P41586 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 620 | 0.81 | 0.86 | 54 | empty |
| 2 | 795 | 0.75 | 0.80 | 61 | empty |
| 3 | 928 | 0.74 | 0.78 | 71 | empty |
| 4 | 108 | 0.67 | 0.91 | 27 | empty |
| 5 | 270 | 0.60 | 0.79 | 39 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2171 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1465 Ų buried · 23 hydrogen bonds · protein-protein
- A–R · 1190 Ų buried · 13 hydrogen bonds · protein-protein
- P–R · 1081 Ų buried · 15 hydrogen bonds · protein-protein
- A–N · 873 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6P9Y · PAC1 GPCR Receptor complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P41586 · AlphaFold monomer V2.0 prediction for pituitary adenylate cyclase- activating polypeptide… · a predicted model of the same protein · chain R against A, TM-score 0.98
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.92
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82
- P18509 · AlphaFold monomer V2.0 prediction for pituitary adenylate cyclase- activating polypeptide… · a predicted model of the same protein · chain P against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P18509
- Every structure of UniProt P41586
- Elsewhere: RCSB PDB 6P9Y · PDBe 6P9Y · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P18509 · UniProt P41586
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