UniProt P41586
Pituitary adenylate cyclase-activating polypeptide type I receptor (P41586)
Pituitary adenylate cyclase-activating polypeptide type I receptor (UniProt P41586): 9 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P41586
- Protein
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 12 · 3 records with a druggable one
Structures
10 records of P41586 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JOD | Pac1-Rshort N-terminal EC domain Pacap(6-38) complex | solution nmr | A | — | — |
| 2JOD | PAC1-rshort N-terminal ec domain PACAP(6-38) complex | solution nmr | A | — | — |
| 6LPB | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | electron microscopy | R | — | — |
| 6LPB | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | electron microscopy | R | — | — |
| 6P9Y | PAC1 GPCR Receptor complex | electron microscopy | R | — | 3 (best 0.74) |
| 6P9Y | PAC1 GPCR receptor complex | electron microscopy | R | — | — |
| 7JQD | Crystal Structure of PAC1r in complex with peptide antagonist | x-ray diffraction | A | — | — |
| 7JQD | Crystal structure of PAC1R in complex with peptide antagonist | x-ray diffraction | A | — | — |
| 8E3X | Cryo-EM structure of the PAC1R-PACAP27-Gs complex | electron microscopy | R | — | 5 (best 0.76) |
| P41586 | AlphaFold monomer V2.0 prediction for pituitary adenylate cyclase- activating polypeptide type I… | predicted | A | — | 4 (best 0.76) |
Experiment against prediction
- 6P9Y chain R against the predicted model P41586: TM-score 0.98, RMSD 0.98 Å
- 6P9Y chain R against the predicted model P41586: TM-score 0.98, RMSD 0.98 Å
- 6LPB chain R against the predicted model P41586: TM-score 0.94, RMSD 1.85 Å
- 6LPB chain R against the predicted model P41586: TM-score 0.94, RMSD 1.85 Å
- 8E3X chain R against the predicted model P41586: TM-score 0.93, RMSD 1.96 Å
- 7JQD chain A against the predicted model P41586: TM-score 0.87, RMSD 1.77 Å
- 7JQD chain A against the predicted model P41586: TM-score 0.87, RMSD 1.77 Å
- 2JOD chain A against the predicted model P41586: TM-score 0.55, RMSD 3.80 Å
- 2JOD chain A against the predicted model P41586: TM-score 0.55, RMSD 3.80 Å
Elsewhere
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