MolNFT v1 · #158357 · protein

Htric-hpfd CLASS4

6NRD · T-complex protein 1 subunit alpha: “Htric-hpfd CLASS4”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #158357 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6NRD
Type: protein
Length: 8,896 residues
Chains: 22
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-complex protein 1 subunit alpha; T-complex protein 1 subunit beta; T-complex protein 1…
UniProt: P17987, P78371, P49368, P50991, P48643, P40227, Q99832, P50990, O60925, Q9UHV9, P61758, Q9NQP4, Q99471, O15212
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 21 distinct chains · 50% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	T-complex protein 1 subunit alpha	protein	521	45% helix, 13% strand	P17987
B	T-complex protein 1 subunit beta	protein	509	50% helix, 15% strand	P78371
C	T-complex protein 1 subunit gamma	protein	509	50% helix, 14% strand	P49368
D	T-complex protein 1 subunit delta	protein	508	50% helix, 13% strand	P50991
E, M	T-complex protein 1 subunit epsilon	protein	517	49% helix, 11% strand	P48643
F	T-complex protein 1 subunit zeta	protein	514	51% helix, 15% strand	P40227
G	T-complex protein 1 subunit eta	protein	512	47% helix, 12% strand	Q99832
H	T-complex protein 1 subunit theta	protein	510	47% helix, 12% strand	P50990
I	T-complex protein 1 subunit alpha	protein	534	44% helix, 11% strand	P17987
J	T-complex protein 1 subunit beta	protein	508	50% helix, 18% strand	P78371
K	T-complex protein 1 subunit gamma	protein	513	48% helix, 11% strand	P49368
L	T-complex protein 1 subunit delta	protein	513	50% helix, 10% strand	P50991
N	T-complex protein 1 subunit zeta	protein	513	49% helix, 14% strand	P40227
O	T-complex protein 1 subunit eta	protein	514	46% helix, 15% strand	Q99832
P	T-complex protein 1 subunit theta	protein	509	49% helix, 12% strand	P50990
1	Prefoldin subunit 1	protein	107	77% helix, 4% strand	O60925
2	Prefoldin subunit 2	protein	103	77% helix, 6% strand	Q9UHV9
3	Prefoldin subunit 3	protein	132	60% helix, 14% strand	P61758
4	Prefoldin subunit 4	protein	104	78% helix, 10% strand	Q9NQP4
5	Prefoldin subunit 5	protein	127	67% helix, 17% strand	Q99471
6	Prefoldin subunit 6	protein	102	74% helix, 2% strand	O15212

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1199	0.84	0.85	110	empty
2	968	0.83	0.84	108	empty
3	507	0.81	0.88	69	empty
4	152	0.80	0.96	42	empty
5	1131	0.80	0.81	71	empty

Interfaces

51 interfaces between chains.

M–O · 3470 Å² buried · 55 hydrogen bonds · protein-protein
E–G · 3194 Å² buried · 67 hydrogen bonds · protein-protein
J–L · 2273 Å² buried · 46 hydrogen bonds · protein-protein
I–L · 2130 Å² buried · 57 hydrogen bonds · protein-protein
I–K · 1965 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

6NRD · hTRiC-hPFD Class4 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17987
Every structure of UniProt P78371
Every structure of UniProt P49368
Every structure of UniProt P50991
Every structure of UniProt P48643
Every structure of UniProt P40227
Every structure of UniProt Q99832
Every structure of UniProt P50990
Every structure of UniProt O60925
Every structure of UniProt Q9UHV9
Every structure of UniProt P61758
Every structure of UniProt Q9NQP4
Every structure of UniProt Q99471
Every structure of UniProt O15212
Elsewhere: RCSB PDB 6NRD · PDBe 6NRD · UniProt P17987 · UniProt P78371 · UniProt P49368 · UniProt P50991 · UniProt P48643 · UniProt P40227 · UniProt Q99832 · UniProt P50990 · UniProt O60925 · UniProt Q9UHV9 · UniProt P61758 · UniProt Q9NQP4 · UniProt Q99471 · UniProt O15212

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