UniProt P50990

T-complex protein 1 subunit theta (P50990)

T-complex protein 1 subunit theta (UniProt P50990): 48 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 222 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P50990
Protein: T-complex protein 1 subunit theta
Experimental structures: 48
Predicted models: 1
Ligands: 3
Pockets: 222 · 33 records with a druggable one

Structures

49 records of P50990 in the MolNFT archive: 48 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6NR8	hTRiC-hPFD Class6	electron microscopy	H, P	—	3 (best 0.84)
6NR8	Htric-hpfd CLASS6	electron microscopy	H, P	—	—
6NR9	hTRiC-hPFD Class5	electron microscopy	H, P	—	3 (best 0.78)
6NR9	Htric-hpfd CLASS5	electron microscopy	H, P	—	—
6NRA	hTRiC-hPFD Class1 (No PFD)	electron microscopy	H, P	—	—
6NRA	Htric-hpfd CLASS1 (no pfd)	electron microscopy	H, P	—	—
6NRB	hTRiC-hPFD Class2	electron microscopy	H, P	—	4 (best 0.79)
6NRB	Htric-hpfd CLASS2	electron microscopy	H, P	—	—
6NRC	hTRiC-hPFD Class3	electron microscopy	H, P	—	6 (best 0.79)
6NRC	Htric-hpfd CLASS3	electron microscopy	H, P	—	—
6NRD	Htric-hpfd CLASS4	electron microscopy	H, P	—	—
6QB8	Human CCT:MLST8 complex	electron microscopy	q, Q	ADP	—
7LUM	Human TRiC in ATP/AlFx closed state	electron microscopy	J, B	—	6 (best 0.85)
7LUM	Human tric in ATP/ALFX closed state	electron microscopy	J, B	—	—
7LUP	Human TRIC/CCT complex with reovirus outer capsid protein sigma-3	electron microscopy	J, B	—	—
7NVL	Human TRiC complex in closed state with nanobody bound (Consensus Map)	electron microscopy	Q, q	ADP, MG, AF3	—
7NVL	Human tric complex in closed state with nanobody bound (consensus MAP)	electron microscopy	Q, q	ADP, MG, AF3	—
7NVM	Human TRiC complex in closed state with nanobody Nb18, actin and PhLP2A bound	electron microscopy	Q, q	ADP, MG, AF3	—
7NVM	Human tric complex in closed state with nanobody NB18, actin and PHLP2A bound	electron microscopy	Q, q	ADP, MG, AF3	—
7NVN	Human TRiC complex in closed state with nanobody and tubulin bound	electron microscopy	Q, q	ADP, MG, AF3	7 (best 0.84)
7NVN	Human tric complex in closed state with nanobody and tubulin bound	electron microscopy	Q, q	ADP, MG, AF3	—
7NVO	Human tric complex in open state with nanobody bound	electron microscopy	Q, q	ADP, MG, AF3	—
7TTN	The beta-tubulin folding intermediate II	electron microscopy	B	AF3, MG, ADP	6 (best 0.83)
7TUB	The beta-tubulin folding intermediate IV	electron microscopy	B	MG, ADP, AF3	5 (best 0.84)
7WZ3	Cryo-EM structure of human TRiC-tubulin-S1 state	electron microscopy	Q, q	ADP	6 (best 0.84)
7X0S	Human TRiC-tubulin-S3	electron microscopy	J, P	ADP, MG, AF3	9 (best 0.87)
7X0V	cryo-EM structure of human TRiC-ADP-AlFx	electron microscopy	J, P	ADP, MG, AF3	6 (best 0.86)
7X3U	cryo-EM structure of human TRiC-ADP	electron microscopy	Q, q	ADP	8 (best 0.82)
7X7Y	Cryo-EM structure of Human TRiC-ATP-open state	electron microscopy	Q, q	—	6 (best 0.82)
8HKI	Human TRiC open state	electron microscopy	Q, q	ADP	10 (best 0.82)
8I1U	Human TRiC-PhLP2A complex in the closed state	electron microscopy	H, P	ADP, MG, AF3	6 (best 0.88)
8I9U	Human TRiC-PhLP2A complex in the open state	electron microscopy	H, P	ADP	5 (best 0.85)
8IB8	Human TRiC-PhLP2A-actin complex in the closed state	electron microscopy	H, P	—	3 (best 0.85)
8SFF	CCT G beta 5 complex closed state 0	electron microscopy	Q, q	ADP, MG, AF3	7 (best 0.84)
8SG9	CCT G beta 5 complex closed state 3	electron microscopy	Q, q	ADP, MG, AF3	9 (best 0.86)
8SGC	CCT G beta 5 complex closed state 2	electron microscopy	Q, q	ADP, MG, AF3	8 (best 0.86)
8SH9	CCT G beta 5 complex best PhLP1 class	electron microscopy	Q, q	ADP, MG, AF3	8 (best 0.86)
8SHA	CCT-G beta 5 complex closed state 4	electron microscopy	Q, q	ADP, MG, AF3	10 (best 0.86)
8SHD	CCT G beta 5 complex closed state 10	electron microscopy	Q, q	ADP, MG, AF3	6 (best 0.86)
8SHE	CCT-G beta 5 complex closed state 8	electron microscopy	Q, q	ADP, MG, AF3	7 (best 0.83)
8SHF	CCT-G beta 5 complex closed state 7	electron microscopy	Q, q	ADP, MG, AF3	8 (best 0.84)
8SHG	CCT G beta 5 complex closed state 9	electron microscopy	Q, q	ADP, MG, AF3	8 (best 0.87)
8SHL	CCT G beta 5 complex closed state 5	electron microscopy	Q, q	ADP, MG, AF3	9 (best 0.84)
8SHN	CCT-G beta 5 complex closed state 6	electron microscopy	Q, q	ADP, MG, AF3	9 (best 0.86)
8SHO	CCT G beta 5 complex close state 11	electron microscopy	Q, q	ADP, MG, AF3	9 (best 0.86)
8SHP	CCT G beta 5 complex closed state 13	electron microscopy	Q, q	ADP, MG, AF3	7 (best 0.86)
8SHQ	CCT G beta 5 complex closed state 12	electron microscopy	Q, q	ADP, MG, AF3	8 (best 0.86)
8SHT	CCT G beta 5 complex closed state 14	electron microscopy	Q, q	ADP, MG, AF3	7 (best 0.86)
P50990	AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit theta (P50990)	predicted	A	—	3 (best 0.80)

Ligands

ADP · Adenosine-5'-diphosphate · in 32 records
AF3 · Aluminum fluoride · in 27 records
MG · Magnesium ion · in 27 records

Experiment against prediction

7NVN chain q against the predicted model P50990: TM-score 0.98, RMSD 1.28 Å
7NVN chain q against the predicted model P50990: TM-score 0.98, RMSD 1.28 Å
7NVN chain Q against the predicted model P50990: TM-score 0.98, RMSD 1.29 Å
7NVN chain Q against the predicted model P50990: TM-score 0.98, RMSD 1.29 Å
7NVL chain Q against the predicted model P50990: TM-score 0.98, RMSD 1.29 Å
7NVL chain Q against the predicted model P50990: TM-score 0.98, RMSD 1.29 Å
7NVO chain Q against the predicted model P50990: TM-score 0.98, RMSD 1.38 Å
7NVM chain q against the predicted model P50990: TM-score 0.97, RMSD 1.43 Å
7NVM chain q against the predicted model P50990: TM-score 0.97, RMSD 1.43 Å
8SFF chain q against the predicted model P50990: TM-score 0.97, RMSD 1.47 Å

Elsewhere

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