MolNFT v1 · #158355 · protein

Htric-hpfd CLASS2

6NRB · T-complex protein 1 subunit alpha: “Htric-hpfd CLASS2”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #158355 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6NRB
Type: protein
Length: 8,896 residues
Chains: 22
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-complex protein 1 subunit alpha; T-complex protein 1 subunit beta; T-complex protein 1…
UniProt: P17987, P78371, P49368, P50991, P48643, P40227, Q99832, P50990, O60925, Q9UHV9, P61758, Q9NQP4, Q99471, O15212
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 21 distinct chains · 49% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	T-complex protein 1 subunit alpha	protein	521	46% helix, 14% strand	P17987
B	T-complex protein 1 subunit beta	protein	509	48% helix, 15% strand	P78371
C	T-complex protein 1 subunit gamma	protein	509	50% helix, 12% strand	P49368
D	T-complex protein 1 subunit delta	protein	508	50% helix, 12% strand	P50991
E, M	T-complex protein 1 subunit epsilon	protein	517	48% helix, 9% strand	P48643
F	T-complex protein 1 subunit zeta	protein	514	51% helix, 14% strand	P40227
G	T-complex protein 1 subunit eta	protein	512	49% helix, 13% strand	Q99832
H	T-complex protein 1 subunit theta	protein	510	44% helix, 12% strand	P50990
I	T-complex protein 1 subunit alpha	protein	534	43% helix, 12% strand	P17987
J	T-complex protein 1 subunit beta	protein	508	48% helix, 16% strand	P78371
K	T-complex protein 1 subunit gamma	protein	513	46% helix, 9% strand	P49368
L	T-complex protein 1 subunit delta	protein	513	47% helix, 11% strand	P50991
N	T-complex protein 1 subunit zeta	protein	513	47% helix, 16% strand	P40227
O	T-complex protein 1 subunit eta	protein	514	46% helix, 12% strand	Q99832
P	T-complex protein 1 subunit theta	protein	509	46% helix, 10% strand	P50990
1	Prefoldin subunit 1	protein	107	77% helix, 5% strand	O60925
2	Prefoldin subunit 2	protein	103	69% helix, 8% strand	Q9UHV9
3	Prefoldin subunit 3	protein	132	64% helix, 16% strand	P61758
4	Prefoldin subunit 4	protein	104	73% helix, 10% strand	Q9NQP4
5	Prefoldin subunit 5	protein	127	68% helix, 12% strand	Q99471
6	Prefoldin subunit 6	protein	102	71% helix, 2% strand	O15212

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	973	0.84	0.85	94	empty
2	229	0.83	0.96	37	empty
3	165	0.82	0.97	37	empty
4	832	0.81	0.83	59	empty
5	559	0.81	0.87	62	empty

Interfaces

46 interfaces between chains.

M–O · 3639 Å² buried · 61 hydrogen bonds · protein-protein
E–G · 3131 Å² buried · 50 hydrogen bonds · protein-protein
J–L · 2361 Å² buried · 44 hydrogen bonds · protein-protein
I–L · 2194 Å² buried · 65 hydrogen bonds · protein-protein
I–K · 2189 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

6NRB · hTRiC-hPFD Class2 · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17987
Every structure of UniProt P78371
Every structure of UniProt P49368
Every structure of UniProt P50991
Every structure of UniProt P48643
Every structure of UniProt P40227
Every structure of UniProt Q99832
Every structure of UniProt P50990
Every structure of UniProt O60925
Every structure of UniProt Q9UHV9
Every structure of UniProt P61758
Every structure of UniProt Q9NQP4
Every structure of UniProt Q99471
Every structure of UniProt O15212
Elsewhere: RCSB PDB 6NRB · PDBe 6NRB · UniProt P17987 · UniProt P78371 · UniProt P49368 · UniProt P50991 · UniProt P48643 · UniProt P40227 · UniProt Q99832 · UniProt P50990 · UniProt O60925 · UniProt Q9UHV9 · UniProt P61758 · UniProt Q9NQP4 · UniProt Q99471 · UniProt O15212

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.