UniProt P48643
T-complex protein 1 subunit epsilon (P48643)
T-complex protein 1 subunit epsilon (UniProt P48643): 60 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 325 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P48643
- Protein
- T-complex protein 1 subunit epsilon
- Experimental structures
- 60
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 325 · 42 records with a druggable one
Structures
61 records of P48643 in the MolNFT archive: 60 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5UYX | Structure of Human T-complex protein 1 subunit epsilon (CCT5) | x-ray diffraction | A, B, C, D | ADP | 20 (best 0.81) |
| 5UYX | Structure of human T-complex protein 1 subunit epsilon (CCT5) | x-ray diffraction | A, B, C, D | ADP | — |
| 5UYZ | Structure of Human T-complex protein 1 subunit epsilon (CCT5) mutant His147Arg | x-ray diffraction | A, B, C, D | ADP, MG | 20 (best 0.79) |
| 5UYZ | Structure of human T-complex protein 1 subunit epsilon (CCT5) mutant HIS147ARG | x-ray diffraction | A, B, C, D | ADP, MG | — |
| 6NR8 | hTRiC-hPFD Class6 | electron microscopy | E, M | — | 7 (best 0.85) |
| 6NR8 | Htric-hpfd CLASS6 | electron microscopy | E, M | — | — |
| 6NR9 | hTRiC-hPFD Class5 | electron microscopy | E, M | — | 6 (best 0.84) |
| 6NR9 | Htric-hpfd CLASS5 | electron microscopy | E, M | — | — |
| 6NRA | hTRiC-hPFD Class1 (No PFD) | electron microscopy | E, M | — | — |
| 6NRA | Htric-hpfd CLASS1 (no pfd) | electron microscopy | E, M | — | — |
| 6NRB | hTRiC-hPFD Class2 | electron microscopy | E, M | — | 5 (best 0.84) |
| 6NRB | Htric-hpfd CLASS2 | electron microscopy | E, M | — | — |
| 6NRC | hTRiC-hPFD Class3 | electron microscopy | E, M | — | 3 (best 0.85) |
| 6NRC | Htric-hpfd CLASS3 | electron microscopy | E, M | — | — |
| 6NRD | hTRiC-hPFD Class4 | electron microscopy | E, M | — | 6 (best 0.84) |
| 6NRD | Htric-hpfd CLASS4 | electron microscopy | E, M | — | — |
| 6QB8 | Human CCT:mLST8 complex | electron microscopy | e, E | — | 7 (best 0.84) |
| 6QB8 | Human CCT:MLST8 complex | electron microscopy | e, E | — | — |
| 7LUM | Human TRiC in ATP/AlFx closed state | electron microscopy | L, D | — | 8 (best 0.87) |
| 7LUM | Human tric in ATP/ALFX closed state | electron microscopy | L, D | — | — |
| 7LUP | Human TRIC/CCT complex with reovirus outer capsid protein sigma-3 | electron microscopy | L, D | — | — |
| 7NVL | Human TRiC complex in closed state with nanobody bound (Consensus Map) | electron microscopy | E, e | ADP, MG, AF3 | — |
| 7NVL | Human tric complex in closed state with nanobody bound (consensus MAP) | electron microscopy | E, e | ADP, MG, AF3 | — |
| 7NVM | Human TRiC complex in closed state with nanobody Nb18, actin and PhLP2A bound | electron microscopy | E, e | ADP, MG, AF3 | — |
| 7NVM | Human tric complex in closed state with nanobody NB18, actin and PHLP2A bound | electron microscopy | E, e | ADP, MG, AF3 | — |
| 7NVN | Human TRiC complex in closed state with nanobody and tubulin bound | electron microscopy | E, e | ADP, MG, AF3 | 7 (best 0.85) |
| 7NVN | Human tric complex in closed state with nanobody and tubulin bound | electron microscopy | E, e | ADP, MG, AF3 | — |
| 7NVO | Human tric complex in open state with nanobody bound | electron microscopy | E, e | ADP | — |
| 7TTN | The beta-tubulin folding intermediate II | electron microscopy | D | MG, ADP, AF3 | 4 (best 0.79) |
| 7TUB | The beta-tubulin folding intermediate IV | electron microscopy | D | MG, ADP, AF3 | 5 (best 0.79) |
| 7WU7 | Prefoldin-tubulin-TRiC complex | electron microscopy | E, M | — | 8 (best 0.85) |
| 7WZ3 | Cryo-EM structure of human TRiC-tubulin-S1 state | electron microscopy | E, e | — | 9 (best 0.84) |
| 7X0S | Human TRiC-tubulin-S3 | electron microscopy | E, e | ADP, MG, AF3 | 8 (best 0.84) |
| 7X0V | cryo-EM structure of human TRiC-ADP-AlFx | electron microscopy | E, e | ADP, MG, AF3 | 8 (best 0.86) |
| 7X3U | cryo-EM structure of human TRiC-ADP | electron microscopy | E, e | ADP | 8 (best 0.85) |
| 7X7Y | Cryo-EM structure of Human TRiC-ATP-open state | electron microscopy | E, e | — | 6 (best 0.85) |
| 8AJM | Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 | electron microscopy | C | — | — |
| 8AJO | Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5 | electron microscopy | C | — | 3 (best 0.85) |
| 8HKI | Human TRiC open state | electron microscopy | E, e | — | 6 (best 0.84) |
| 8I1U | Human TRiC-PhLP2A complex in the closed state | electron microscopy | E, M | ADP, MG, AF3 | 9 (best 0.88) |
| 8I9U | Human TRiC-PhLP2A complex in the open state | electron microscopy | E, M | — | 5 (best 0.85) |
| 8IB8 | Human TRiC-PhLP2A-actin complex in the closed state | electron microscopy | E, M | — | 5 (best 0.88) |
| 8SFE | Open state CCT-G beta 5 complex | electron microscopy | e, E | ADP | 6 (best 0.86) |
| 8SFF | CCT G beta 5 complex closed state 0 | electron microscopy | E, e | ADP, MG, AF3 | 7 (best 0.86) |
| 8SG8 | CCT G beta 5 complex closed state 1 | electron microscopy | E, e | ADP, MG, AF3 | 7 (best 0.85) |
| 8SG9 | CCT G beta 5 complex closed state 3 | electron microscopy | E, e | ADP, MG, AF3 | 7 (best 0.86) |
| 8SGC | CCT G beta 5 complex closed state 2 | electron microscopy | E, e | ADP, MG, AF3 | 9 (best 0.86) |
| 8SGL | CCT G beta 5 complex closed state 15 | electron microscopy | E, e | ADP, MG, AF3 | 10 (best 0.86) |
| 8SH9 | CCT G beta 5 complex best PhLP1 class | electron microscopy | E, e | ADP, MG, AF3 | 9 (best 0.86) |
| 8SHA | CCT-G beta 5 complex closed state 4 | electron microscopy | E, e | ADP, MG, AF3 | 7 (best 0.86) |
| 8SHD | CCT G beta 5 complex closed state 10 | electron microscopy | E, e | ADP, MG, AF3 | 9 (best 0.89) |
| 8SHE | CCT-G beta 5 complex closed state 8 | electron microscopy | E, e | ADP, MG, AF3 | 9 (best 0.88) |
| 8SHF | CCT-G beta 5 complex closed state 7 | electron microscopy | E, e | ADP, MG, AF3 | 7 (best 0.87) |
| 8SHG | CCT G beta 5 complex closed state 9 | electron microscopy | E, e | ADP, MG, AF3 | 10 (best 0.87) |
| 8SHL | CCT G beta 5 complex closed state 5 | electron microscopy | E, e | ADP, MG, AF3 | 9 (best 0.85) |
| 8SHN | CCT-G beta 5 complex closed state 6 | electron microscopy | E, e | ADP, MG, AF3 | 8 (best 0.90) |
| 8SHO | CCT G beta 5 complex close state 11 | electron microscopy | E, e | ADP, MG, AF3 | 9 (best 0.86) |
| 8SHP | CCT G beta 5 complex closed state 13 | electron microscopy | E, e | ADP, MG, AF3 | 9 (best 0.88) |
| 8SHQ | CCT G beta 5 complex closed state 12 | electron microscopy | E, e | ADP, MG, AF3 | 8 (best 0.88) |
| 8SHT | CCT G beta 5 complex closed state 14 | electron microscopy | E, e | ADP, MG, AF3 | 10 (best 0.86) |
1 record more on the page itself.
Ligands
Experiment against prediction
- 8HKI chain E against the predicted model P48643: TM-score 0.97, RMSD 1.06 Å
- 7NVO chain E against the predicted model P48643: TM-score 0.97, RMSD 1.09 Å
- 8HKI chain e against the predicted model P48643: TM-score 0.96, RMSD 1.56 Å
- 8I1U chain E against the predicted model P48643: TM-score 0.96, RMSD 1.99 Å
- 7LUM chain L against the predicted model P48643: TM-score 0.95, RMSD 2.05 Å
- 7LUM chain L against the predicted model P48643: TM-score 0.95, RMSD 2.05 Å
- 8SHA chain E against the predicted model P48643: TM-score 0.95, RMSD 2.12 Å
- 7LUP chain L against the predicted model P48643: TM-score 0.95, RMSD 2.06 Å
- 8SHL chain E against the predicted model P48643: TM-score 0.95, RMSD 2.14 Å
- 7NVL chain E against the predicted model P48643: TM-score 0.95, RMSD 2.12 Å
Elsewhere
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