Research workbench
Htric-hpfd CLASS4
Analyse Htric-hpfd CLASS4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NRD
- Type
- protein
- Length
- 8,896 residues
- Chains
- 22
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-complex protein 1 subunit alpha; T-complex protein 1 subunit beta; T-complex protein 1…
- UniProt
- P17987, P78371, P49368, P50991, P48643, P40227, Q99832, P50990, O60925, Q9UHV9, P61758, Q9NQP4, Q99471, O15212
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 21 distinct chains · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-complex protein 1 subunit alpha | protein | 521 | 45% helix, 13% strand | P17987 |
| B | T-complex protein 1 subunit beta | protein | 509 | 50% helix, 15% strand | P78371 |
| C | T-complex protein 1 subunit gamma | protein | 509 | 50% helix, 14% strand | P49368 |
| D | T-complex protein 1 subunit delta | protein | 508 | 50% helix, 13% strand | P50991 |
| E, M | T-complex protein 1 subunit epsilon | protein | 517 | 49% helix, 11% strand | P48643 |
| F | T-complex protein 1 subunit zeta | protein | 514 | 51% helix, 15% strand | P40227 |
| G | T-complex protein 1 subunit eta | protein | 512 | 47% helix, 12% strand | Q99832 |
| H | T-complex protein 1 subunit theta | protein | 510 | 47% helix, 12% strand | P50990 |
| I | T-complex protein 1 subunit alpha | protein | 534 | 44% helix, 11% strand | P17987 |
| J | T-complex protein 1 subunit beta | protein | 508 | 50% helix, 18% strand | P78371 |
| K | T-complex protein 1 subunit gamma | protein | 513 | 48% helix, 11% strand | P49368 |
| L | T-complex protein 1 subunit delta | protein | 513 | 50% helix, 10% strand | P50991 |
| N | T-complex protein 1 subunit zeta | protein | 513 | 49% helix, 14% strand | P40227 |
| O | T-complex protein 1 subunit eta | protein | 514 | 46% helix, 15% strand | Q99832 |
| P | T-complex protein 1 subunit theta | protein | 509 | 49% helix, 12% strand | P50990 |
| 1 | Prefoldin subunit 1 | protein | 107 | 77% helix, 4% strand | O60925 |
| 2 | Prefoldin subunit 2 | protein | 103 | 77% helix, 6% strand | Q9UHV9 |
| 3 | Prefoldin subunit 3 | protein | 132 | 60% helix, 14% strand | P61758 |
| 4 | Prefoldin subunit 4 | protein | 104 | 78% helix, 10% strand | Q9NQP4 |
| 5 | Prefoldin subunit 5 | protein | 127 | 67% helix, 17% strand | Q99471 |
| 6 | Prefoldin subunit 6 | protein | 102 | 74% helix, 2% strand | O15212 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1199 | 0.84 | 0.85 | 110 | empty |
| 2 | 968 | 0.83 | 0.84 | 108 | empty |
| 3 | 507 | 0.81 | 0.88 | 69 | empty |
| 4 | 152 | 0.80 | 0.96 | 42 | empty |
| 5 | 1131 | 0.80 | 0.81 | 71 | empty |
Interfaces
51 interfaces between chains.
- M–O · 3470 Ų buried · 55 hydrogen bonds · protein-protein
- E–G · 3194 Ų buried · 67 hydrogen bonds · protein-protein
- J–L · 2273 Ų buried · 46 hydrogen bonds · protein-protein
- I–L · 2130 Ų buried · 57 hydrogen bonds · protein-protein
- I–K · 1965 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 6NRD · hTRiC-hPFD Class4 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17987
- Every structure of UniProt P78371
- Every structure of UniProt P49368
- Every structure of UniProt P50991
- Every structure of UniProt P48643
- Every structure of UniProt P40227
- Every structure of UniProt Q99832
- Every structure of UniProt P50990
- Every structure of UniProt O60925
- Every structure of UniProt Q9UHV9
- Every structure of UniProt P61758
- Every structure of UniProt Q9NQP4
- Every structure of UniProt Q99471
- Every structure of UniProt O15212
- Elsewhere: RCSB PDB 6NRD · PDBe 6NRD · UniProt P17987 · UniProt P78371 · UniProt P49368 · UniProt P50991 · UniProt P48643 · UniProt P40227 · UniProt Q99832 · UniProt P50990 · UniProt O60925 · UniProt Q9UHV9 · UniProt P61758 · UniProt Q9NQP4 · UniProt Q99471 · UniProt O15212
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