MolNFT v1 · #157696 · protein
Cryo-EM structure of tetrameric PTCH1 in complex with shhnp (form I)
6N7G: “Cryo-EM structure of tetrameric PTCH1 in complex with shhnp (form I)”. Electron microscopy, 5 ligands (CLR, PLM, NAG). MolNFT v1 #157696 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6N7G
- Type
- protein
- Length
- 4,306 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q13635, Q15465
- Ligands
- CLR, PLM, NAG, CA, ZN
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | — | protein | 991 | — | Q13635 |
| B, E | — | protein | 988 | — | Q13635 |
| C, F | — | protein | 174 | — | Q15465 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 10 copies · chains A, B, C, D, E, F
- PLM · Palmitic acid · ligand · 2 copies · chains B, C, E, F
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 28 copies · chains A, B, D, E
- CA · Calcium ion · metal · 4 copies · chains C, F
- ZN · Zinc ion · metal · 2 copies · chains C, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6N7G · Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form I) · the same entry in another collection · chain F against F, TM-score 1.00
- Q13635 · AlphaFold monomer V2.0 prediction for protein patched homolog 1 (Q13635) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q15465 · AlphaFold monomer V2.0 prediction for sonic hedgehog protein (Q15465) · a predicted model of the same protein · chain C against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13635
- Every structure of UniProt Q15465
- Elsewhere: RCSB PDB 6N7G · PDBe 6N7G · UniProt Q13635 · UniProt Q15465
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