UniProt Q13635
Protein patched homolog 1 (Q13635)
Protein patched homolog 1 (UniProt Q13635): 28 experimental structures on GenesisL1, 5 ligands bound, 128 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13635
- Protein
- Protein patched homolog 1
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 128 · 9 records with a druggable one
Structures
28 records of Q13635 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6DMB | Cryo-EM structure of human PTCH1 | electron microscopy | A | NAG, Y01 | — |
| 6DMO | Cryo-EM structure of human PTCH1 with three mutations L282Q/T500F/P504L | electron microscopy | A | NAG | — |
| 6DMY | Cryo-EM structure of human Ptch1 and ShhN complex | electron microscopy | A | NAG, Y01 | 19 (best 0.87) |
| 6DMY | Cryo-EM structure of human PTCH1 and shhn complex | electron microscopy | A | NAG, Y01 | — |
| 6E1H | Structure of 2:1 human Ptch1-Shh-N complex | electron microscopy | A, B | PLM | 20 (best 0.86) |
| 6E1H | Structure of 2:1 human PTCH1-shh-N complex | electron microscopy | A, B | PLM | — |
| 6N7G | Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form I) | electron microscopy | A, B, D, E | NAG, CLR, PLM | — |
| 6N7G | Cryo-EM structure of tetrameric PTCH1 in complex with shhnp (form I) | electron microscopy | A, B, D, E | NAG, CLR, PLM | — |
| 6N7H | Cryo-EM structure of the 2:1 hPtch1-Shhp complex | electron microscopy | A, B | NAG, CLR, PLM | — |
| 6N7H | Cryo-EM structure of the 2:1 HPTCH1-shhp complex | electron microscopy | A, B | NAG, CLR, PLM | — |
| 6N7K | Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form II) | electron microscopy | A, B, D, E | NAG, CLR, PLM | 20 (best 0.88) |
| 6N7K | Cryo-EM structure of tetrameric PTCH1 in complex with shhnp (form II) | electron microscopy | A, B, D, E | NAG, CLR, PLM | — |
| 6OEU | Structure of human Patched1 | electron microscopy | A | NAG | 15 (best 0.88) |
| 6OEU | Structure of human PATCHED1 | electron microscopy | A | NAG | — |
| 6OEV | Structure of human Patched1 in complex with native Sonic Hedgehog | electron microscopy | A | NAG | 19 (best 0.78) |
| 6OEV | Structure of human PATCHED1 in complex with native sonic hedgehog | electron microscopy | A | PLM, NAG | — |
| 6RMG | Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II | electron microscopy | A | NAG, Y01 | — |
| 6RMG | Structure of PTCH1 bound to a modified hedgehog ligand shhn-C24II | electron microscopy | A | NAG, Y01 | — |
| 6RTW | Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and… | x-ray diffraction | A | NAG, Y01 | 4 (best 0.76) |
| 6RTW | Crystal structure of the patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and… | x-ray diffraction | A | NAG, Y01 | — |
| 6RTX | Crystal structure of the Patched-1 (PTCH1) ectodomain 1 | x-ray diffraction | A | NAG | 3 (best 0.63) |
| 6RTX | Crystal structure of the patched-1 (PTCH1) ectodomain 1 | x-ray diffraction | A | NAG | — |
| 6RTY | Crystal structure of the patched ectodomain in complex with nanobody NB64 | x-ray diffraction | A | NAG | — |
| 6RVC | Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 | x-ray diffraction | A, B, C | NAG, SO4 | 9 (best 0.51) |
| 6RVC | Crystal structure of patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 | x-ray diffraction | A, B, C | NAG, SO4 | — |
| 6RVD | Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex | electron microscopy | A, B | NAG, CLR, PLM | 19 (best 0.87) |
| 6RVD | Revised cryo-EM structure of the human 2:1 PTCH1-shh complex | electron microscopy | A, B | NAG, CLR, PLM | — |
| Q13635 | AlphaFold monomer V2.0 prediction for protein patched homolog 1 (Q13635) | — | — | — |
Ligands
Elsewhere
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