UniProt Q15465
Sonic hedgehog protein (Q15465)
Sonic hedgehog protein (UniProt Q15465): 26 experimental structures on GenesisL1, 6 ligands bound, 25 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q15465
- Protein
- Sonic hedgehog protein
- Experimental structures
- 26
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 25 · 4 records with a druggable one
Structures
26 records of Q15465 in the MolNFT archive: 26 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3HO5 | Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex | x-ray diffraction | H | — | — |
| 3HO5 | Crystal structure of hedgehog-interacting protein (hhip) and sonic hedgehog (shh) complex | x-ray diffraction | H | — | — |
| 3M1N | Crystal structure of Human Sonic Hedgehog N-terminal domain | x-ray diffraction | A, B | — | — |
| 3M1N | Crystal structure of human sonic hedgehog N-terminal domain | x-ray diffraction | A, B | — | — |
| 3MXW | Crystal structure Sonic hedgehog bound to the 5E1 fab fragment | x-ray diffraction | A | — | — |
| 3MXW | Crystal structure sonic hedgehog bound to the 5E1 Fab fragment | x-ray diffraction | A | — | — |
| 6DMY | Cryo-EM structure of human PTCH1 and shhn complex | electron microscopy | B | ZN, CA | — |
| 6E1H | Structure of 2:1 human Ptch1-Shh-N complex | electron microscopy | C | ZN, CA, PLM | 9 (best 0.84) |
| 6E1H | Structure of 2:1 human PTCH1-shh-N complex | electron microscopy | C | PLM, ZN, CA | — |
| 6N7G | Cryo-EM structure of tetrameric Ptch1 in complex with ShhNp (form I) | electron microscopy | C, F | CLR, ZN, CA, PLM | — |
| 6N7G | Cryo-EM structure of tetrameric PTCH1 in complex with shhnp (form I) | electron microscopy | C, F | CLR, ZN, CA, PLM | — |
| 6N7H | Cryo-EM structure of the 2:1 hPtch1-Shhp complex | electron microscopy | C | CLR, ZN, CA, PLM | — |
| 6N7H | Cryo-EM structure of the 2:1 HPTCH1-shhp complex | electron microscopy | C | CLR, ZN, CA, PLM | — |
| 6N7K | Cryo-EM structure of tetrameric PTCH1 in complex with shhnp (form II) | electron microscopy | C, F | CLR, ZN, CA, PLM | — |
| 6OEV | Structure of human Patched1 in complex with native Sonic Hedgehog | electron microscopy | C | ZN | 6 (best 0.78) |
| 6OEV | Structure of human PATCHED1 in complex with native sonic hedgehog | electron microscopy | C | PLM, ZN | — |
| 6PJV | Structure of human sonic hedgehog in complex with zinc and magnesium | x-ray diffraction | A | MG, ZN, CL | — |
| 6RMG | Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II | electron microscopy | B | ZN | — |
| 6RMG | Structure of PTCH1 bound to a modified hedgehog ligand shhn-C24II | electron microscopy | B | ZN | — |
| 6RVD | Revised cryo-EM structure of the human 2:1 PTCH1-shh complex | electron microscopy | C | PLM, CLR, ZN, CA | — |
| 7E2I | Cryo-EM structure of HDISP1NNN-shhn | electron microscopy | G | ZN | — |
| 7MHZ | Human Hedgehog acyltransferase (HHAT) in complex with a palmitoylated Hedgehog peptide product and… | electron microscopy | B | PLM | 2 (best 0.81) |
| 7MHZ | Human hedgehog acyltransferase (hhat) in complex with a palmitoylated hedgehog peptide product and… | electron microscopy | B | PLM | — |
| 7RHQ | Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog | electron microscopy | C | CLR, ZN, CA, PLM | 8 (best 0.89) |
| 7RHQ | Cryo-EM structure of xenopus patched-1 in complex with GAS1 and sonic hedgehog | electron microscopy | C | CLR, ZN, CA, PLM | — |
| Q15465 | AlphaFold monomer V2.0 prediction for sonic hedgehog protein (Q15465) | — | — | — |
Ligands
Elsewhere
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