Xfel crystal structure of human melatonin receptor MT2 in complex with ramelteon

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• JEV · N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6ME9 · XFEL crystal structure of human melatonin receptor MT2 in complex with ramelteon · the same entry in another collection · chain A against A, TM-score 1.00
• P49286 · AlphaFold monomer V2.0 prediction for melatonin receptor type 1B (P49286) · a predicted model of the same protein · chain B against A, TM-score 0.71
• P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain B against A, TM-score 0.26
• P00268 · AlphaFold monomer V2.0 prediction for rubredoxin (P00268) · a predicted model of the same protein · chain A against A, TM-score 0.12

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0ABE7
• Every structure of UniProt P49286
• Every structure of UniProt P00268
• Elsewhere: RCSB PDB 6ME9 · PDBe 6ME9 · UniProt P0ABE7 · UniProt P49286 · UniProt P00268