UniProt P49286
Melatonin receptor type 1B (P49286)
Melatonin receptor type 1B (UniProt P49286): 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49286
- Protein
- Melatonin receptor type 1B
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 5 · 1 record with a druggable one
Structures
7 records of P49286 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6ME6 | Xfel crystal structure of human melatonin receptor MT2 in complex with 2-phenylmelatonin | x-ray diffraction | A, B | JEY, ZN | — |
| 6ME7 | Xfel crystal structure of human melatonin receptor MT2 (H208A) in complex with 2-phenylmelatonin | x-ray diffraction | A, B | JEY, ZN | — |
| 6ME8 | Xfel crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin | x-ray diffraction | A, B | JEY, ZN | — |
| 6ME9 | XFEL crystal structure of human melatonin receptor MT2 in complex with ramelteon | x-ray diffraction | A, B | JEV, ZN | — |
| 6ME9 | Xfel crystal structure of human melatonin receptor MT2 in complex with ramelteon | x-ray diffraction | A, B | JEV, ZN | — |
| 7VH0 | MT2-remalteon-gi complex | electron microscopy | A | JEV | — |
| P49286 | AlphaFold monomer V2.0 prediction for melatonin receptor type 1B (P49286) | predicted | A | — | 5 (best 0.84) |
Ligands
Experiment against prediction
- 6ME7 chain A against the predicted model P00268: TM-score 0.12, RMSD 0.51 Å
- 6ME6 chain A against the predicted model P00268: TM-score 0.12, RMSD 0.52 Å
- 6ME8 chain A against the predicted model P00268: TM-score 0.12, RMSD 0.62 Å
- 6ME9 chain A against the predicted model P00268: TM-score 0.12, RMSD 0.61 Å
- 6ME9 chain A against the predicted model P00268: TM-score 0.12, RMSD 0.61 Å
- 7VH0 chain A against the predicted model P49286: TM-score 0.93, RMSD 1.81 Å
- 6ME8 chain A against the predicted model P49286: TM-score 0.66, RMSD 2.19 Å
- 6ME9 chain A against the predicted model P49286: TM-score 0.66, RMSD 2.18 Å
- 6ME9 chain A against the predicted model P49286: TM-score 0.66, RMSD 2.18 Å
- 6ME6 chain A against the predicted model P49286: TM-score 0.66, RMSD 2.18 Å
Elsewhere
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