MolNFT v1 · #136891 · protein
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant
5V6Y: “Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and…”. X-ray diffraction, 2 ligands (GLC, NH2). MolNFT v1 #136891 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5V6Y
- Type
- protein
- Length
- 2,253 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P0AEY0, O60894, Q16602, P35318
- Ligands
- GLC, NH2
Structure
x-ray diffraction · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 550 | — | P0AEY0, O60894, Q16602 |
| B | — | protein | 551 | — | P0AEY0, O60894, Q16602 |
| C | — | protein | 549 | — | P0AEY0, O60894, Q16602 |
| D | — | protein | 547 | — | P0AEY0, O60894, Q16602 |
| E, F | — | protein | 15 | — | P35318 |
| G, H | — | protein | 13 | — | P35318 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 8 copies · chains A, B, C, D
- NH2 · Amino group · ion · 4 copies · chains A, E, B, F, C, G, D, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5V6Y · Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound… · the same entry in another collection · chain A against A, TM-score 1.00
- P35318 · AlphaFold monomer V2.0 prediction for pro-adrenomedullin (P35318) · a predicted model of the same protein · chain H against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEY0
- Every structure of UniProt O60894
- Every structure of UniProt Q16602
- Every structure of UniProt P35318
- Elsewhere: RCSB PDB 5V6Y · PDBe 5V6Y · UniProt P0AEY0 · UniProt O60894 · UniProt Q16602 · UniProt P35318
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