UniProt P0AEY0
Maltose-binding periplasmic protein (P0AEY0)
Maltose-binding periplasmic protein (UniProt P0AEY0), EC 1.14.11.51, 2.8.2.-: 150 experimental structures and 1 predicted model on GenesisL1, 36 ligands bound, 1,325 pockets. Binding sites, druggability and experiment against…
- UniProt
- P0AEY0
- Protein
- Maltose-binding periplasmic protein
- EC
- 1.14.11.51, 2.8.2.-, 3.1.-.-, 3.4.21.89, 3.5.1.98, 3.5.4.38, 3.6.4.-, 5.2.1.8
- Experimental structures
- 150
- Predicted models
- 1
- Ligands
- 36
- Pockets
- 1,325 · 149 records with a druggable one
Structures
151 records of P0AEY0 in the MolNFT archive: 150 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HSJ | Sarr mbp fusion structure | x-ray diffraction | A, B | GLC | 13 (best 0.78) |
| 1HSJ | Sarr mbp fusion structure | x-ray diffraction | A, B | GLC | 13 (best 0.78) |
| 2V93 | Equillibrium mixture of open and partially-closed species in the apo state of maltodextrin-binding… | solution nmr | A | MXT | 4 (best 0.69) |
| 2V93 | Equillibrium mixture of open and partially-closed species in the apo state of maltodextrin-binding… | solution nmr | A | MXT | 4 (best 0.68) |
| 3IO4 | Huntingtin amino-terminal region with 17 Gln residues - Crystal C90 | x-ray diffraction | A, B, C | ZN, CA | 18 (best 0.74) |
| 3IO4 | Huntingtin amino-terminal region with 17 gln residues - crystal C90 | x-ray diffraction | A, B, C | ZN, CA | 18 (best 0.74) |
| 3IO6 | Huntingtin amino-terminal region with 17 Gln residues - crystal C92-a | x-ray diffraction | A, C, B | ZN, CA | 15 (best 0.73) |
| 3IO6 | Huntingtin amino-terminal region with 17 gln residues - crystal C92-a | x-ray diffraction | A, C, B | ZN, CA | 15 (best 0.73) |
| 3OSQ | Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent… | x-ray diffraction | A | GLC, SO4 | 5 (best 0.76) |
| 3OSQ | Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent… | x-ray diffraction | A | C12, GLC, SO4 | 5 (best 0.76) |
| 3OSR | Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent… | x-ray diffraction | A, B | GLC | 11 (best 0.77) |
| 3OSR | Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent… | x-ray diffraction | A, B | C12, GLC | 11 (best 0.77) |
| 3VD8 | Crystal structure of human AIM2 PYD domain with MBP fusion | x-ray diffraction | A | GLC, K | 4 (best 0.71) |
| 3VD8 | Crystal structure of human AIM2 pyd domain with mbp fusion | x-ray diffraction | A | GLC, K | 4 (best 0.71) |
| 4FEB | Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta) | x-ray diffraction | A, B, C | ZN, NA | 19 (best 0.74) |
| 4FEB | Crystal structure of HTT36Q3H-EX1-X1-C2(BETA) | x-ray diffraction | A, B, C | ZN, NA | 19 (best 0.74) |
| 4MY2 | Crystal Structure of Norrin in fusion with Maltose Binding Protein | x-ray diffraction | A | GLC | 5 (best 0.72) |
| 4MY2 | Crystal structure of norrin in fusion with maltose binding protein | x-ray diffraction | A | GLC | 5 (best 0.72) |
| 4WGI | A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1) | x-ray diffraction | A | GLC, 3M6, MG | 6 (best 0.71) |
| 4WGI | A single diastereomer of a macrolactam core binds specifically to myeloid cell leukemia 1 (MCL1) | x-ray diffraction | A | GLC, 3M6, MG | 6 (best 0.71) |
| 4WRN | Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein | x-ray diffraction | A, B | GLC, NAG, ZN | 16 (best 0.85) |
| 4WRN | Crystal structure of the polymerization region of human UROMODULIN/TAMM-horsfall protein | x-ray diffraction | A, B | GLC, NAG, ZN | 16 (best 0.85) |
| 4WTH | Ataxin-3 Carboxy Terminal Region - Crystal C2 (triclinic) | x-ray diffraction | A, B | GLC, ZN | 7 (best 0.69) |
| 4WTH | Ataxin-3 carboxy terminal region - crystal C2 (triclinic) | x-ray diffraction | A, B | GLC, ZN | 7 (best 0.69) |
| 4WVG | Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB). | x-ray diffraction | A | GLC | 3 (best 0.71) |
| 4WVG | Crystal structure of the type-I signal peptidase from staphylococcus aureus (spsb). | x-ray diffraction | A | GLC | 3 (best 0.71) |
| 4WVH | Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with… | x-ray diffraction | A | GLC | 3 (best 0.70) |
| 4WVH | Crystal structure of the type-I signal peptidase from staphylococcus aureus (spsb) in complex with… | x-ray diffraction | A | GLC | 3 (best 0.70) |
| 4WVI | Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with… | x-ray diffraction | A | GLC | 4 (best 0.72) |
| 4WVI | Crystal structure of the type-I signal peptidase from staphylococcus aureus (spsb) in complex with… | x-ray diffraction | A | GLC | 4 (best 0.72) |
| 4WVJ | Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with… | x-ray diffraction | A | GLC | 5 (best 0.71) |
| 4WVJ | Crystal structure of the type-I signal peptidase from staphylococcus aureus (spsb) in complex with… | x-ray diffraction | A | GLC | 5 (best 0.71) |
| 4XA2 | Structure of the Major Type IV pilin of Acinetobacter baumannii | x-ray diffraction | A, B | GLC | 9 (best 0.76) |
| 4XA2 | Structure of the major type IV pilin of acinetobacter baumannii | x-ray diffraction | A, B | GLC | 9 (best 0.76) |
| 4XAI | Crystal structure of red flour beetle NR2E1/TLX | x-ray diffraction | A, B | GLC | 11 (best 0.74) |
| 4XAJ | Crystal structure of human NR2E1/TLX | x-ray diffraction | A, C, B, D | GLC | 20 (best 0.83) |
| 4XHS | Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction | x-ray diffraction | A, B | GLC, NA | 12 (best 0.72) |
| 4XHS | Crystal structure of human NLRP12 pyd domain and implication in homotypic interaction | x-ray diffraction | A, B | GLC, NA | 12 (best 0.72) |
| 4YS9 | Ataxin-3 Carboxy-Terminal Region - Crystal C1 (tetragonal) | x-ray diffraction | B | GLC, ZN | 4 (best 0.72) |
| 4YS9 | Ataxin-3 carboxy-terminal region - crystal C1 (tetragonal) | x-ray diffraction | B | GLC, ZN | 4 (best 0.72) |
| 5BJZ | Crystal structure of maltose binding protein in complex with an allosteric synthetic antibody | x-ray diffraction | B, A | GLC, CL | 17 (best 0.73) |
| 5BMY | Crystal structure of hPin1 WW domain (5-21) fused with maltose-binding protein | x-ray diffraction | A | GLC | 5 (best 0.71) |
| 5BMY | Crystal structure of HPIN1 ww domain (5-21) fused with maltose-binding protein | x-ray diffraction | A | GLC | 5 (best 0.71) |
| 5C7R | Revealing surface waters on an antifreeze protein by fusion protein crystallography | x-ray diffraction | A, B | GLC, SO4 | 6 (best 0.75) |
| 5C7R | Revealing surface waters on an antifreeze protein by fusion protein crystallography | x-ray diffraction | A, B | GLC, SO4 | 6 (best 0.75) |
| 5CL1 | Complex structure of norrin with human frizzled 4 | x-ray diffraction | A, B | NAG | 12 (best 0.78) |
| 5DFM | Structure of tetrahymena telomerase P19 fused to mbp | x-ray diffraction | A, B | GLC, SO4 | 13 (best 0.81) |
| 5E24 | Structure of the Su(H)-Hairless-DNA Repressor Complex | x-ray diffraction | A, C | GLC | 7 (best 0.79) |
| 5E24 | Structure of the SU(H)-hairless-DNA repressor complex | x-ray diffraction | A, C | GLC | 7 (best 0.79) |
| 5E7U | MBP-MamC loop structure, a magnetite biomineralizing protein from Magnetospirillium magneticum AMB-1 | x-ray diffraction | A | GLC, SO4 | 3 (best 0.74) |
| 5E7U | Mbp-mamc loop structure, a magnetite biomineralizing protein from magnetospirillium magneticum amb-1 | x-ray diffraction | A | GLC, SO4 | 3 (best 0.74) |
| 5EDU | Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin A | x-ray diffraction | B, A | GLC, TSN, ZN, K | 6 (best 0.80) |
| 5EDU | Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin a | x-ray diffraction | B, A | GLC, TSN, ZN, K | 6 (best 0.80) |
| 5FIO | DARPins as a new tool for experimental phasing in protein crystallography | x-ray diffraction | B | — | 6 (best 0.64) |
| 5FIO | Darpins as a new tool for experimental phasing in protein crystallography | x-ray diffraction | B | — | 6 (best 0.64) |
| 5GPP | Crystal structure of zebrafish asc pyd domain | x-ray diffraction | A, B | GLC, SO4 | 16 (best 0.74) |
| 5GPQ | Crystal Structure of zebrafish ASC CARD Domain | x-ray diffraction | A | GLC | 4 (best 0.75) |
| 5GPQ | Crystal structure of zebrafish asc card domain | x-ray diffraction | A | GLC | 4 (best 0.75) |
| 5II4 | Crystal structure of red abalone VERL repeat 1 with linker at 2.0 A resolution | x-ray diffraction | A | GLC | 4 (best 0.72) |
| 5II4 | Crystal structure of red abalone verl repeat 1 with linker at 2.0 a resolution | x-ray diffraction | A | GLC | 4 (best 0.72) |
91 records more on the page itself.
Ligands
- GLC · alpha-D-glucopyranose · in 104 records
- ZN · Zinc ion · in 28 records
- NA · Sodium ion · in 20 records
- CA · Calcium ion · in 12 records
- SO4 · Sulfate ion · in 12 records
- CL · Chloride ion · in 11 records
- A3P · Adenosine-3'-5'-diphosphate · in 6 records
- BDP · beta-D-glucopyranuronic acid · in 6 records
- GNS · 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose · in 6 records
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 4 records
- JLE · (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid · in 4 records
- K · Potassium ion · in 4 records
- MG · Magnesium ion · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- 3M6 · (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid · in 2 records
- 70R · (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid · in 2 records
- C12 · 2-(1-amino-2-hydroxypropyl)-4-(4-hydroxybenzyl)-1-(2-oxoethyl)-1H-imidazol-5-olate · in 2 records
- CTN · 4-amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone · in 2 records
- DCM · 2'-deoxycytidine-5'-monophosphate · in 2 records
- J1N · 2-[(6-ethyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl) amino]-3-oxidanyl-propanoic acid · in 2 records
- J7G · 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid · in 2 records
- J7J · N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea · in 2 records
- JKQ · (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]amino]propanoic acid · in 2 records
- JL8 · (2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid · in 2 records
- JLB · (2~{R})-2-[6-ethyl-5-(1~{H}-indol-5-yl)thieno[2,3-d]pyrimidin-4-yl]oxypropanoic acid · in 2 records
- JLH · (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-ethyl-thieno[2, 3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid · in 2 records
- MXT · 1-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)pyrrolidine-2,5-dione · in 2 records
- NH2 · Amino group · in 2 records
- OJW · (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[(2-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid · in 2 records
- OK2 · (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-(pyrazin-2-ylmethoxy)phenyl]propanoic acid · in 2 records
Experiment against prediction
- 5TTD chain B against the predicted model P0AEY0: TM-score 1.00, RMSD 0.35 Å
- 5E24 chain A against the predicted model P0AEY0: TM-score 1.00, RMSD 0.51 Å
- 5LDF chain M against the predicted model P0AEY0: TM-score 0.99, RMSD 0.61 Å
- 5E7U chain A against the predicted model P0AEY0: TM-score 0.97, RMSD 0.67 Å
- 4YS9 chain B against the predicted model P0AEY0: TM-score 0.96, RMSD 0.48 Å
- 6EQZ chain A against the predicted model P0AEY0: TM-score 0.95, RMSD 1.32 Å
- 6EQZ chain G against the predicted model P0AEY0: TM-score 0.95, RMSD 1.24 Å
- 5C7R chain B against the predicted model P19614: TM-score 0.15, RMSD 0.84 Å
- 5C7R chain B against the predicted model P19614: TM-score 0.15, RMSD 0.84 Å
- 5C7R chain A against the predicted model P19614: TM-score 0.15, RMSD 0.93 Å
Elsewhere
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