UniProt Q16602
Calcitonin gene-related peptide type 1 receptor (Q16602)
Calcitonin gene-related peptide type 1 receptor (UniProt Q16602): 34 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 63 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q16602
- Protein
- Calcitonin gene-related peptide type 1 receptor
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 63 · 8 records with a druggable one
Structures
35 records of Q16602 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3AQF | Crystal structure of the human CRLR/RAMP2 extracellular complex | x-ray diffraction | B | — | — |
| 3AQF | Crystal structure of the human CRLR/RAMP2 extracellular complex | x-ray diffraction | B | — | — |
| 3N7P | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site… | x-ray diffraction | A, B, C, J | — | — |
| 3N7P | Crystal structure of the ectodomain complex of the cgrp receptor, a class-B GPCR, reveals the site… | x-ray diffraction | A, B, C, J | — | — |
| 3N7R | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site… | x-ray diffraction | A, B | — | — |
| 3N7R | Crystal structure of the ectodomain complex of the cgrp receptor, a class-B GPCR, reveals the site… | x-ray diffraction | A, B | — | — |
| 3N7S | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site… | x-ray diffraction | A, B | — | — |
| 3N7S | Crystal structure of the ectodomain complex of the cgrp receptor, a class-B GPCR, reveals the site… | x-ray diffraction | A, B | — | — |
| 4RWF | Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin | x-ray diffraction | A | — | — |
| 4RWF | Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin | x-ray diffraction | A | — | — |
| 4RWG | Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity CGRP… | x-ray diffraction | A, B, C | — | — |
| 4RWG | Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity cgrp… | x-ray diffraction | A, B, C | — | — |
| 5V6Y | Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity… | x-ray diffraction | A, B, C, D | GLC | 20 (best 0.81) |
| 5V6Y | Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity… | x-ray diffraction | A, B, C, D | NH2, GLC | — |
| 6D1U | Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with… | x-ray diffraction | A, B, C | NH2, GLC, NA | — |
| 6E3Y | Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor | electron microscopy | R | — | 7 (best 0.76) |
| 6E3Y | Cryo-EM structure of the active, gs-protein complexed, human cgrp receptor | electron microscopy | R | NH2 | — |
| 6UMG | Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor | x-ray diffraction | C, c | — | 8 (best 0.63) |
| 6UMG | Crystal structure of erenumab Fab bound to the extracellular domain of cgrp receptor | x-ray diffraction | C, c | — | — |
| 6UUN | Cryoem structure of the active adrenomedullin 1 receptor G protein complex with adrenomedullin… | electron microscopy | R | — | — |
| 6UUS | Cryoem structure of the active adrenomedullin 2 receptor G protein complex with adrenomedullin… | electron microscopy | R | — | — |
| 6UVA | Cryoem structure of the active adrenomedullin 2 receptor G protein complex with adrenomedullin 2… | electron microscopy | R | — | — |
| 6V2E | Crystal structure of the human CLR:RAMP2 extracellular domain heterodimer with bound high-affinity… | x-ray diffraction | A | GLC, NH2 | — |
| 6ZHO | Crystal structure of a cgrp receptor ectodomain heterodimer with bound high affinity inhibitor | x-ray diffraction | A | GLC, QLQ | — |
| 6ZIS | Crystal structure of a CGRP receptor ectodomain heterodimer with bound high affinity inhibitor | x-ray diffraction | A | GLC, 3N6 | 7 (best 0.82) |
| 6ZIS | Crystal structure of a cgrp receptor ectodomain heterodimer with bound high affinity inhibitor | x-ray diffraction | A | GLC, 3N6 | — |
| 7KNT | CryoEM structure of the apo-CGRP receptor in a detergent micelle | electron microscopy | R | — | 4 (best 0.70) |
| 7KNT | Cryoem structure of the apo-cgrp receptor in a detergent micelle | electron microscopy | R | — | — |
| 7KNU | Cryoem structure of the cgrp receptor with bound cgrp peptide in a detergent micelle | electron microscopy | R | — | — |
| 7P0F | Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor… | x-ray diffraction | A | GLC, 7IR | — |
| 7P0I | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor Compound… | x-ray diffraction | A | GLC, 7IU | 6 (best 0.83) |
| 7P0I | Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor compound… | x-ray diffraction | A | GLC, 7IU | — |
| 8AX5 | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor… | x-ray diffraction | A | GLC, OKU | 7 (best 0.84) |
| 8AX6 | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor… | x-ray diffraction | A | GLC, OP9 | 4 (best 0.85) |
| Q16602 | AlphaFold monomer V2.0 prediction for calcitonin gene-related peptide type 1 receptor (Q16602) | predicted | A | — | — |
Ligands
- GLC · alpha-D-glucopyranose · in 12 records
- NH2 · Amino group · in 4 records
- 3N6 · N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl) carbonyl]pentyl}-3,5-dibromo-nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide · in 2 records
- 7IU · (1S,20E)-10-(benzofuran-3-ylmethyl)-12-methyl-15,18-dioxa-5,9,12,24,26-pentazapentacyclo[20.5.2.11,4.13, 7.025,28]hentriaconta-3(30),4,6,20,22(29),23,25(28)-heptaene-8,11,27-trione · in 2 records
- 7IR · (1S,10R,23E)-12-methyl-10-[(7-methyl-1H-indazol-5-yl) methyl]-15,18,21-trioxa-5,9,12,27,29-pentazapentacyclo[23.5.2.11,4.13,7.028, 31]tetratriaconta-3(33),4,6,23,25(32),26,28(31)-heptaene-8,11,30-trione · in 1 record
- NA · Sodium ion · in 1 record
- OKU · (1~{R},10~{R},20~{E})-12-methyl-10-[(7-methyl-2~{H}-indazol-5-yl)methyl]-15,18-dioxa-9,12,24,26-tetrazapentacyclo[20.5.2.1^{1,4}.1^{3,7}.0^{25,28}]hentriaconta-3,5,7(30),20,22,24,28-heptaene-8,11,27-trione · in 1 record
- OP9 · (1~{S},10~{R},20~{E})-12-methyl-10-[(7-methyl-2~{H}-indazol-5-yl)methyl]-15,18-dioxa-9,12,24,26-tetrazapentacyclo[20.5.2.1^{1,4}.1^{3,7}.0^{25,28}]hentriaconta-3(30),4,6,20,22,24,28-heptaene-8,11,27-trione · in 1 record
- QLQ · ~{N}-[(2~{R})-3-(7-methyl-2~{H}-indazol-5-yl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-piperidin-4-yl-1-(4-pyridin-4-ylpiperazin-1-yl)propan-2-yl]amino]propan-2-yl]-2-oxidanylidene-spiro[1~{h}-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide · in 1 record
Experiment against prediction
- 3N7P chain J against the predicted model Q16602: TM-score 0.97, RMSD 0.68 Å
- 3N7P chain J against the predicted model Q16602: TM-score 0.97, RMSD 0.68 Å
- 3N7R chain B against the predicted model Q16602: TM-score 0.97, RMSD 0.68 Å
- 3N7R chain B against the predicted model Q16602: TM-score 0.97, RMSD 0.68 Å
- 3N7R chain A against the predicted model Q16602: TM-score 0.96, RMSD 0.76 Å
- 3N7R chain A against the predicted model Q16602: TM-score 0.96, RMSD 0.76 Å
- 3N7S chain A against the predicted model Q16602: TM-score 0.95, RMSD 1.01 Å
- 3N7S chain A against the predicted model Q16602: TM-score 0.95, RMSD 1.01 Å
- 3N7P chain B against the predicted model Q16602: TM-score 0.95, RMSD 0.87 Å
- 3N7P chain B against the predicted model Q16602: TM-score 0.95, RMSD 0.87 Å
Elsewhere
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