Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with epoxyketone inhibitor 14

Structure

x-ray diffraction · 14 distinct chains.

Ligands and binding sites

• 6N5 · ~{N}-[(2~{S})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · ligand · 4 copies · chains H, I, K, L, V, W, Y, Z
• MG · Magnesium ion · metal · 9 copies · chains G, N, I, Y, J, K, W, L, V, a, Z
• CL · Chloride ion · ion · 2 copies · chains G, H, U, V
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 2 copies · chains H, Y

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5L68 · Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in… · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P23639
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• Every structure of UniProt O09061
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• Every structure of UniProt P38624
• Elsewhere: RCSB PDB 5L68 · PDBe 5L68 · UniProt P23639 · UniProt P23638 · UniProt P40303 · UniProt P32379 · UniProt P40302 · UniProt P21242 · UniProt P21243 · UniProt P25043 · UniProt P25451 · UniProt P22141 · UniProt P28063 · UniProt P30656 · UniProt P23724 · UniProt O09061 · UniProt P30657 · UniProt P38624