UniProt O09061

Proteasome subunit beta type-6,Proteasome subunit beta type-1,Proteasome subunit beta type-6,Proteasome subunit beta type-1,Proteasome subunit beta type-6 (O09061)

Proteasome subunit beta type-6,Proteasome subunit beta type-1,Proteasome subunit beta type-6,Proteasome subunit beta type-1,Proteasome subunit beta type-6 (UniProt O09061), EC 3.4.25.1: 24 experimental structures and 1 predicted…

UniProt: O09061
Protein: Proteasome subunit beta type-6,Proteasome subunit beta type-1,Proteasome…
EC: 3.4.25.1
Experimental structures: 24
Predicted models: 1
Ligands: 9
Pockets: 19 · 3 records with a druggable one

Structures

25 records of O09061 in the MolNFT archive: 24 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
3UNB	Mouse constitutive 20S proteasome in complex with PR-957	x-ray diffraction	L, Z, n, 2	—	—
3UNB	Mouse constitutive 20S proteasome in complex with pr-957	x-ray diffraction	L, Z, n, 2	—	—
3UNE	Mouse constitutive 20S proteasome	x-ray diffraction	L, Z, n, 2	—	—
3UNE	Mouse constitutive 20S proteasome	x-ray diffraction	L, Z, n, 2	—	—
3UNF	Mouse 20S immunoproteasome in complex with PR-957	x-ray diffraction	L, Z	—	—
3UNF	Mouse 20S immunoproteasome in complex with pr-957	x-ray diffraction	L, Z	—	—
3UNH	Mouse 20S immunoproteasome	x-ray diffraction	L, Z	—	—
3UNH	Mouse 20S immunoproteasome	x-ray diffraction	L, Z	—	—
5L65	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	3BV, MG	—
5L65	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	3BV, MG	—
5L66	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	BO2, MG	6 (best 0.82)
5L66	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	BO2, MG	—
5L67	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	39V, MG	7 (best 0.83)
5L67	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	39V, MG	—
5L68	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	6N5, MG	—
5L68	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	6N5, MG	—
5L69	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	79P, MG	5 (best 0.75)
5L69	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	79P, MG	—
5L6A	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	79L, MG	—
5L6A	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	79L, MG	—
5L6B	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	04C, MG	—
5L6B	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	04C, MG	—
5L6C	Yeast 20S proteasome with mouse beta5i (1-138) and mouse beta6 (97-111; 118-133) in complex with…	x-ray diffraction	L, Z	6NV, MG	—
5L6C	Yeast 20S proteasome with mouse BETA5I (1-138) and mouse BETA6 (97- 111; 118-133) in complex with…	x-ray diffraction	L, Z	6NV, MG	—
O09061	AlphaFold monomer V2.0 prediction for proteasome subunit beta type-1 (O09061)	predicted	A	—	1 (best 0.29)

Ligands

MG · Magnesium ion · in 16 records
04C · 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol · in 2 records
39V · N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(2S, 4R)-5-hydroxy-4-methyl-3-oxo-1-phenylpentan-2-yl]-L-tryptophanamide · in 2 records
3BV · N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide · in 2 records
6N5 · ~{N}-[(2~{S})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · in 2 records
6NV · ~{N}-[(2~{R})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · in 2 records
79L · (2~{S})-3-(4-methoxyphenyl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 2 records
79P · (2~{S})-3-(1~{H}-indol-3-yl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 2 records
BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 2 records

Experiment against prediction

3UNE chain L against the predicted model O09061: TM-score 0.99, RMSD 0.41 Å
3UNE chain L against the predicted model O09061: TM-score 0.99, RMSD 0.41 Å
3UNB chain L against the predicted model O09061: TM-score 0.99, RMSD 0.46 Å
3UNB chain L against the predicted model O09061: TM-score 0.99, RMSD 0.46 Å
3UNH chain L against the predicted model O09061: TM-score 0.99, RMSD 0.49 Å
3UNH chain L against the predicted model O09061: TM-score 0.99, RMSD 0.49 Å
3UNF chain L against the predicted model O09061: TM-score 0.99, RMSD 0.52 Å
3UNF chain L against the predicted model O09061: TM-score 0.99, RMSD 0.52 Å
5L69 chain L against the predicted model O09061: TM-score 0.94, RMSD 0.78 Å
5L69 chain L against the predicted model O09061: TM-score 0.94, RMSD 0.78 Å

Elsewhere

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.