UniProt P21242
Probable proteasome subunit alpha type-7 (P21242)
Probable proteasome subunit alpha type-7 (UniProt P21242), EC 3.4.25.1: 581 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 276 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P21242
- Protein
- Probable proteasome subunit alpha type-7
- EC
- 3.4.25.1
- Experimental structures
- 581
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 276 · 60 records with a druggable one
Structures
582 records of P21242 in the MolNFT archive: 581 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FNT | Crystal structure of the 20S proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | G, U | — | — |
| 1FNT | Crystal structure of the 20S proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | G, U | — | — |
| 1G0U | A gated channel into the proteasome core particle | x-ray diffraction | F, T | — | — |
| 1G0U | A gated channel into the proteasome core particle | x-ray diffraction | F, T | — | — |
| 1G65 | Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of… | x-ray diffraction | F, T | — | — |
| 1G65 | Crystal structure of EPOXOMICIN:20S proteasome reveals a molecular basis for selectivity of… | x-ray diffraction | F, T | — | — |
| 1JD2 | Crystal Structure of the yeast 20S Proteasome:TMC-95A complex: A non-covalent Proteasome Inhibitor | x-ray diffraction | F, 1 | — | — |
| 1JD2 | Crystal structure of the yeast 20S PROTEASOME:TMC-95A complex: a non- covalent proteasome inhibitor | x-ray diffraction | F, 1 | — | — |
| 1RYP | Crystal structure of the 20S proteasome from yeast at 2.4 ångströms resolution | x-ray diffraction | G, U | — | — |
| 1RYP | Crystal structure of the 20S proteasome from yeast at 2.4 ångströms resolution | x-ray diffraction | G, U | — | — |
| 1Z7Q | Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | G, U | — | — |
| 1Z7Q | Crystal structure of the 20S proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | G, U | — | — |
| 2F16 | Crystal structure of the yeast 20S proteasome in complex with bortezomib | x-ray diffraction | F, T | — | — |
| 2F16 | Crystal structure of the yeast 20S proteasome in complex with bortezomib | x-ray diffraction | F, T | — | — |
| 2FAK | Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome | x-ray diffraction | F, T | — | — |
| 2FAK | Crystal structure of salinosporamide a in complex with the yeast 20S proteasome | x-ray diffraction | F, T | — | — |
| 2GPL | TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors | x-ray diffraction | F, T | — | — |
| 2GPL | Tmc-95 based biphenyl-ether macrocycles: specific proteasome inhibitors | x-ray diffraction | F, T | — | — |
| 2ZCY | yeast 20S proteasome:syringolin A-complex | x-ray diffraction | F, T | — | — |
| 2ZCY | Yeast 20S PROTEASOME:SYRINGOLIN a-complex | x-ray diffraction | F, T | — | — |
| 3BDM | yeast 20S proteasome:glidobactin A-complex | x-ray diffraction | F, T | — | — |
| 3BDM | Yeast 20S PROTEASOME:GLIDOBACTIN a-complex | x-ray diffraction | F, T | — | — |
| 3D29 | Proteasome inhibition by fellutamide B | x-ray diffraction | F, T | — | — |
| 3DY3 | Crystal structure of yeast 20S proteasome in complex with the epimer form of spirolactacystin | x-ray diffraction | F, T | — | — |
| 3DY3 | Crystal structure of yeast 20S proteasome in complex with the epimer form of spirolactacystin | x-ray diffraction | F, T | — | — |
| 3DY4 | Crystal structure of yeast 20S proteasome in complex with spirolactacystin | x-ray diffraction | F, T | — | — |
| 3DY4 | Crystal structure of yeast 20S proteasome in complex with spirolactacystin | x-ray diffraction | F, T | — | — |
| 3E47 | Crystal Structure of the Yeast 20S Proteasome in Complex with Homobelactosin C | x-ray diffraction | F, T | — | — |
| 3E47 | Crystal structure of the yeast 20S proteasome in complex with homobelactosin C | x-ray diffraction | F, T | — | — |
| 3GPJ | Crystal structure of the yeast 20S proteasome in complex with syringolin B | x-ray diffraction | F, T | — | — |
| 3GPJ | Crystal structure of the yeast 20S proteasome in complex with syringolin B | x-ray diffraction | F, T | — | — |
| 3GPT | Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow… | x-ray diffraction | F, T | — | — |
| 3GPT | Crystal structure of the yeast 20S proteasome in complex with salinosporamide derivatives: slow… | x-ray diffraction | F, T | — | — |
| 3GPW | Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives… | x-ray diffraction | F, T | — | — |
| 3GPW | Crystal structure of the yeast 20S proteasome in complex with salinosporamide derivatives… | x-ray diffraction | F, T | — | — |
| 3HYE | Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide | x-ray diffraction | F, T | — | — |
| 3HYE | Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide | x-ray diffraction | F, T | — | — |
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | G, g | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | G, g | — | — |
| 3MG0 | Structure of yeast 20S proteasome with bortezomib | x-ray diffraction | F, T | — | — |
| 3MG0 | Structure of yeast 20S proteasome with bortezomib | x-ray diffraction | F, T | — | — |
| 3MG4 | Structure of yeast 20S proteasome with Compound 1 | x-ray diffraction | F, T | — | — |
| 3MG4 | Structure of yeast 20S proteasome with compound 1 | x-ray diffraction | F, T | — | — |
| 3MG6 | Structure of yeast 20S open-gate proteasome with Compound 6 | x-ray diffraction | F, T | — | — |
| 3MG6 | Structure of yeast 20S open-gate proteasome with compound 6 | x-ray diffraction | F, T | — | — |
| 3MG7 | Structure of yeast 20S open-gate proteasome with Compound 8 | x-ray diffraction | F, T | — | — |
| 3MG7 | Structure of yeast 20S open-gate proteasome with compound 8 | x-ray diffraction | F, T | — | — |
| 3MG8 | Structure of yeast 20S open-gate proteasome with Compound 16 | x-ray diffraction | F, T | — | — |
| 3MG8 | Structure of yeast 20S open-gate proteasome with compound 16 | x-ray diffraction | F, T | — | — |
| 3NZJ | Crystal structure of yeast 20S proteasome in complex with ligand 2a | x-ray diffraction | F, T | — | — |
| 3NZJ | Crystal structure of yeast 20S proteasome in complex with ligand 2A | x-ray diffraction | F, T | — | — |
| 3NZW | Crystal structure of the yeast 20S proteasome in complex with 2b | x-ray diffraction | F, T | — | — |
| 3NZW | Crystal structure of the yeast 20S proteasome in complex with 2B | x-ray diffraction | F, T | — | — |
| 3NZX | Crystal structure of the yeast 20S proteasome in complex with ligand 2c | x-ray diffraction | F, T | — | — |
| 3NZX | Crystal structure of the yeast 20S proteasome in complex with ligand 2C | x-ray diffraction | F, T | — | — |
| 3OEU | Structure of yeast 20S open-gate proteasome with Compound 24 | x-ray diffraction | F, T | — | — |
| 3OEU | Structure of yeast 20S open-gate proteasome with compound 24 | x-ray diffraction | F, T | — | — |
| 3OEV | Structure of yeast 20S open-gate proteasome with Compound 25 | x-ray diffraction | F, T | — | — |
| 3OEV | Structure of yeast 20S open-gate proteasome with compound 25 | x-ray diffraction | F, T | — | — |
| 3OKJ | Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition | x-ray diffraction | F, T | — | — |
522 records more on the page itself.
Ligands
- CL · Chloride ion · in 2 records
Experiment against prediction
- 5L5U chain F against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 4QVL chain F against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 5L5U chain T against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 5BXL chain T against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 5BXL chain F against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 4QVY chain F against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 5L5R chain F against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 5L5R chain T against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 5CZ6 chain F against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
- 6HTB chain F against the predicted model P21242: TM-score 1.00, RMSD 0.27 Å
Elsewhere
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