UniProt P38624
Proteasome subunit beta type-1 (P38624)
Proteasome subunit beta type-1 (UniProt P38624), EC 3.4.25.1: 576 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 183 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P38624
- Protein
- Proteasome subunit beta type-1
- EC
- 3.4.25.1
- Experimental structures
- 576
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 183 · 54 records with a druggable one
Structures
577 records of P38624 in the MolNFT archive: 576 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FNT | Crystal structure of the 20S proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | H, V | — | — |
| 1FNT | Crystal structure of the 20S proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | H, V | — | — |
| 1G0U | A gated channel into the proteasome core particle | x-ray diffraction | N, 2 | — | — |
| 1G0U | A gated channel into the proteasome core particle | x-ray diffraction | N, 2 | — | — |
| 1G65 | Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of… | x-ray diffraction | N, 2 | — | — |
| 1G65 | Crystal structure of EPOXOMICIN:20S proteasome reveals a molecular basis for selectivity of… | x-ray diffraction | N, 2 | — | — |
| 1JD2 | Crystal Structure of the yeast 20S Proteasome:TMC-95A complex: A non-covalent Proteasome Inhibitor | x-ray diffraction | N, U | — | — |
| 1JD2 | Crystal structure of the yeast 20S PROTEASOME:TMC-95A complex: a non- covalent proteasome inhibitor | x-ray diffraction | N, U | — | — |
| 1RYP | Crystal structure of the 20S proteasome from yeast at 2.4 ångströms resolution | x-ray diffraction | H, V | — | — |
| 1RYP | Crystal structure of the 20S proteasome from yeast at 2.4 ångströms resolution | x-ray diffraction | H, V | — | — |
| 1Z7Q | Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | H, V | — | — |
| 1Z7Q | Crystal structure of the 20S proteasome from yeast in complex with the proteasome activator PA26… | x-ray diffraction | H, V | — | — |
| 2F16 | Crystal structure of the yeast 20S proteasome in complex with bortezomib | x-ray diffraction | N, 2 | — | — |
| 2F16 | Crystal structure of the yeast 20S proteasome in complex with bortezomib | x-ray diffraction | N, 2 | — | — |
| 2FAK | Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome | x-ray diffraction | N, 2 | — | — |
| 2FAK | Crystal structure of salinosporamide a in complex with the yeast 20S proteasome | x-ray diffraction | N, 2 | — | — |
| 2GPL | TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors | x-ray diffraction | N, 2 | — | — |
| 2GPL | Tmc-95 based biphenyl-ether macrocycles: specific proteasome inhibitors | x-ray diffraction | N, 2 | — | — |
| 2ZCY | yeast 20S proteasome:syringolin A-complex | x-ray diffraction | N, 1 | — | — |
| 2ZCY | Yeast 20S PROTEASOME:SYRINGOLIN a-complex | x-ray diffraction | N, 1 | — | — |
| 3BDM | yeast 20S proteasome:glidobactin A-complex | x-ray diffraction | N, 1 | — | — |
| 3BDM | Yeast 20S PROTEASOME:GLIDOBACTIN a-complex | x-ray diffraction | N, 1 | — | — |
| 3D29 | Proteasome Inhibition by Fellutamide B | x-ray diffraction | N, 2 | — | — |
| 3D29 | Proteasome inhibition by fellutamide B | x-ray diffraction | N, 2 | — | — |
| 3DY3 | Crystal structure of yeast 20S proteasome in complex with the epimer form of spirolactacystin | x-ray diffraction | N, 2 | — | — |
| 3DY3 | Crystal structure of yeast 20S proteasome in complex with the epimer form of spirolactacystin | x-ray diffraction | N, 2 | — | — |
| 3DY4 | Crystal structure of yeast 20S proteasome in complex with spirolactacystin | x-ray diffraction | N, 2 | — | — |
| 3DY4 | Crystal structure of yeast 20S proteasome in complex with spirolactacystin | x-ray diffraction | N, 2 | — | — |
| 3E47 | Crystal Structure of the Yeast 20S Proteasome in Complex with Homobelactosin C | x-ray diffraction | N, 2 | — | — |
| 3E47 | Crystal structure of the yeast 20S proteasome in complex with homobelactosin C | x-ray diffraction | N, 2 | — | — |
| 3GPJ | Crystal structure of the yeast 20S proteasome in complex with syringolin B | x-ray diffraction | N, 2 | — | — |
| 3GPJ | Crystal structure of the yeast 20S proteasome in complex with syringolin B | x-ray diffraction | N, 2 | — | — |
| 3GPT | Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow… | x-ray diffraction | N, 2 | — | — |
| 3GPT | Crystal structure of the yeast 20S proteasome in complex with salinosporamide derivatives: slow… | x-ray diffraction | N, 2 | — | — |
| 3GPW | Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives… | x-ray diffraction | N, 2 | — | — |
| 3GPW | Crystal structure of the yeast 20S proteasome in complex with salinosporamide derivatives… | x-ray diffraction | N, 2 | — | — |
| 3HYE | Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide | x-ray diffraction | N, 2 | — | — |
| 3HYE | Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide | x-ray diffraction | N, 2 | — | — |
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | 3, h | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | 3, h | — | — |
| 3MG0 | Structure of yeast 20S proteasome with bortezomib | x-ray diffraction | N, 2 | — | — |
| 3MG0 | Structure of yeast 20S proteasome with bortezomib | x-ray diffraction | N, 2 | — | — |
| 3MG4 | Structure of yeast 20S proteasome with Compound 1 | x-ray diffraction | N, 2 | — | — |
| 3MG4 | Structure of yeast 20S proteasome with compound 1 | x-ray diffraction | N, 2 | — | — |
| 3MG6 | Structure of yeast 20S open-gate proteasome with Compound 6 | x-ray diffraction | N, 2 | — | — |
| 3MG6 | Structure of yeast 20S open-gate proteasome with compound 6 | x-ray diffraction | N, 2 | — | — |
| 3MG7 | Structure of yeast 20S open-gate proteasome with Compound 8 | x-ray diffraction | N, 2 | — | — |
| 3MG7 | Structure of yeast 20S open-gate proteasome with compound 8 | x-ray diffraction | N, 2 | — | — |
| 3MG8 | Structure of yeast 20S open-gate proteasome with Compound 16 | x-ray diffraction | N, 2 | — | — |
| 3MG8 | Structure of yeast 20S open-gate proteasome with compound 16 | x-ray diffraction | N, 2 | — | — |
| 3NZJ | Crystal structure of yeast 20S proteasome in complex with ligand 2a | x-ray diffraction | N, 2 | — | — |
| 3NZJ | Crystal structure of yeast 20S proteasome in complex with ligand 2A | x-ray diffraction | N, 2 | — | — |
| 3NZW | Crystal structure of the yeast 20S proteasome in complex with 2b | x-ray diffraction | N, 2 | — | — |
| 3NZW | Crystal structure of the yeast 20S proteasome in complex with 2B | x-ray diffraction | N, 2 | — | — |
| 3NZX | Crystal structure of the yeast 20S proteasome in complex with ligand 2c | x-ray diffraction | N, 2 | — | — |
| 3NZX | Crystal structure of the yeast 20S proteasome in complex with ligand 2C | x-ray diffraction | N, 2 | — | — |
| 3OEU | Structure of yeast 20S open-gate proteasome with Compound 24 | x-ray diffraction | N, 2 | — | — |
| 3OEU | Structure of yeast 20S open-gate proteasome with compound 24 | x-ray diffraction | N, 2 | — | — |
| 3OEV | Structure of yeast 20S open-gate proteasome with Compound 25 | x-ray diffraction | N, 2 | — | — |
| 3OEV | Structure of yeast 20S open-gate proteasome with compound 25 | x-ray diffraction | N, 2 | — | — |
517 records more on the page itself.
Ligands
- MG · Magnesium ion · in 182 records
- CL · Chloride ion · in 37 records
- SO4 · Sulfate ion · in 24 records
- 3BV · N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide · in 12 records
- BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 10 records
- 04C · 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol · in 5 records
- GQK · (2~{S})-3-(4-methoxyphenyl)-~{N}-[(2~{S},3~{R})-4-methyl-3,4-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 5 records
- 6N5 · ~{N}-[(2~{S})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · in 2 records
- ALD · N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide · in 2 records
- EQB · (2~{S},3~{S})-3-methyl-2-[(1~{R})-2-[[(2~{S})-3-methyl-1-[[(2~{S})-3-methyl-1-oxidanylidene-1-phenylmethoxy-butan-2-yl]amino]-1-oxidanylidene-butan-2-yl]amino]-1-oxidanyl-2-oxidanylidene-ethyl]pentanoic acid · in 2 records
- EQE · (2~{S},3~{R})-4-[[(2~{S})-3-methyl-1-[[(2~{S})-3-methyl-1-oxidanylidene-1-phenylmethoxy-butan-2-yl]amino]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanyl-4-oxidanylidene-2-propan-2-yl-butanoic acid · in 2 records
- F6K · Homosalinosporamide A - bound form · in 2 records
- GWZ · (2~{S})-~{N}-[(2~{S})-1-[[(3~{R},4~{S})-2,6-dimethyl-2, 3-bis(oxidanyl)heptan-4-yl]amino]-1-oxidanylidene-3-phenyl-propan-2-yl]-4-methyl-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino)-4-phenyl-butanoyl]amino]pentanamide · in 2 records
- 5BY · {2-[2-(2-{4-[(1E)-4-{[(2S)-1-{[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]amino}-1-oxo-3-phenylpropan-2-yl]amino}-4-oxobut-1-en-1-yl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethoxy}acetic acid · in 1 record
- 5BZ · [(1~{R})-1-[[(2~{S})-2-(hex-5-ynoylamino)-3-phenyl-propanoyl]amino]-3-methyl-butyl]boronic acid · in 1 record
- A1IF8 · azanylidene-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(1S)-2-cyclohexyl-1-[(2R,3S,6R,7S)-3-methanoyl-2,6-dimethyl-6,7-bis(oxidanyl)-1,4-oxazepan-7-yl]ethyl]amino]-1-oxidanylidene-hexan-2-yl]carbamoyl]-4,4-bis(fluoranyl)pyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethyl]imino-azanium · in 1 record
- EPW · Cystargolide B- bound form · in 1 record
- VSZ · Cystargolide A (bound) · in 1 record
Experiment against prediction
- 5L5Z chain N against the predicted model P38624: TM-score 1.00, RMSD 0.21 Å
- 5L5Z chain b against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 4NO1 chain N against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 5JHR chain b against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 5JHR chain N against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 4QVN chain N against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 4QW1 chain N against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 4QVL chain N against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 5L66 chain N against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
- 4YA2 chain N against the predicted model P38624: TM-score 1.00, RMSD 0.22 Å
Elsewhere
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