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Ligand · SLA

SLA · Omuralide, open form

SLA, Omuralide, open form (C10 H17 N O4, 215.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
SLA
Formula
C10 H17 N O4
Class
ligand
Structures
8
PDB entries
4

Binding sites

SLA in 8 structures; the first of them:

  • 3DY4 · Crystal structure of yeast 20S proteasome in complex with spirolactacystin · SLA H301 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, ALA46, GLY47 and 4 more
  • 4FWG · Crystal structure of the Lon-like protease MtaLonC in complex with lactacystin · SLA A801 · binds LEU502, VAL503, VAL504, PHE542, GLU579, GLY580, ASP581, SER582 and 4 more
  • 4QZZ · yCP in complex with Omuralide · SLA H301 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, GLY45, ALA46 and 5 more
  • 4R00 · yCP beta5-C52F mutant in complex with Omuralide · SLA H301 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, GLY45, ALA46 and 4 more
  • 3DY4 · Crystal structure of yeast 20S proteasome in complex with spirolactacystin · SLA H301 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, ALA46, GLY47 and 4 more
  • 4FWG · Crystal structure of the lon-like protease mtalonc in complex with lactacystin · SLA A801 · binds LEU502, VAL503, VAL504, PHE542, GLU579, GLY580, ASP581, SER582 and 4 more
  • 4QZZ · Ycp in complex with omuralide · SLA H301 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, GLY45, ALA46 and 5 more
  • 4R00 · Ycp BETA5-C52F mutant in complex with omuralide · SLA H301 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, GLY45, ALA46 and 4 more

Residues it binds most

ALA 34, THR 32, SER 34, GLY 34, ARG 32, LYS 34, TYR 24, VAL 14, CYS 12, MET 12 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • CL · Chloride ion
  • PO4 · Phosphate ion

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