GL1X · GenesisL1 explorer

Ligand · ALD

ALD · N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide

ALD, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide (C26 H43 N3 O5, 477.6 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (13 PDB entries). Every binding site with its residues…

Component
ALD
Formula
C26 H43 N3 O5
Class
ligand
Structures
16
PDB entries
13

Binding sites

ALD in 16 structures; the first of them:

  • 5D0T · Yeast 20S proteasome beta5-D166N mutant in complex with MG132 · ALD K301 · binds THR1, ARG19, ALA20, THR21, ALA22, ALA27, VAL31, LYS33 and 11 more
  • 5FGH · Yeast 20S proteasome beta5-K33A mutant (propeptide expressed in trans) in complex with… · ALD H301 · binds THR1, SER20, THR21, GLN22, ALA27, CYS31, LYS33, GLY45 and 8 more
  • 7BE7 · Crystal structure of MG-132 covalently bound to the main protease (3CLpro/Mpro) of… · ALD A401 · binds HIS41, MET49, PHE140, LEU141, ASN142, GLY143, SER144, CYS145 and 12 more
  • 7CUU · Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with MG132 · ALD A502 · binds HIS41, MET49, TYR54, PHE140, LEU141, ASN142, GLY143, SER144 and 13 more
  • 7NG6 · Crystal structure of MG-132 covalently bound to the main protease (3CLpro/Mpro) of… · ALD A701 · binds HIS41, MET49, TYR54, PHE140, LEU141, ASN142, GLY143, SER144 and 13 more
  • 7QKD · Crystal structure of human Cathepsin L in complex with covalently bound MG132 · ALD A301 · binds GLN19, GLY23, SER24, CYS25, TRP26, GLY61, GLU63, CYS65 and 10 more
  • 7WQB · SARS-CoV-2 main protease mutant (P168A) in complex with MG-132 · ALD A401 · binds HIS41, MET49, TYR54, PHE140, LEU141, ASN142, GLY143, SER144 and 12 more
  • 7WQK · wild-type SARS-CoV-2 main protease in complex with MG-132 · ALD A401 · binds HIS41, MET49, PHE140, ASN142, CYS145, HIS163, HIS164, MET165 and 8 more
  • 8P54 · Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 obtained in presence… · ALD A401 · binds HIS41, MET49, TYR54, PHE140, LEU141, ASN142, GLY143, SER144 and 13 more
  • 8P55 · Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 obtained in presence… · ALD A402 · binds HIS41, TYR54, PHE140, LEU141, ASN142, GLY143, SER144, CYS145 and 12 more
  • 7BE7 · Crystal structure of mg-132 covalently bound to the main protease (3CLPRO/MPRO) of… · ALD A401 · binds HIS41, ASN142, GLY143, SER144, CYS145, HIS163, HIS164, MET165 and 7 more
  • 7BGP · Crystal structure of mg-132 covalently bound to the main protease (3CLPRO/MPRO) of… · ALD A402 · binds HIS41, ASN142, GLY143, SER144, CYS145, HIS163, HIS164, MET165 and 7 more
  • 7CUU · Crystal structure of the SARS-cov-2 (COVID-19) main protease in complex with MG132 · ALD A502 · binds HIS41, MET49, PHE140, LEU141, ASN142, GLY143, SER144, CYS145 and 11 more
  • 7NF5 · Crystal structure of mg-132 covalently bound to the main protease (3CLPRO/MPRO) of… · ALD A401 · binds HIS41, MET49, PHE140, ASN142, GLY143, SER144, CYS145, HIS163 and 9 more
  • 7NG3 · Crystal structure of mg-132 covalently bound to the main protease (3CLPRO/MPRO) of… · ALD A402 · binds HIS41, MET49, PHE140, LEU141, ASN142, GLY143, SER144, CYS145 and 12 more
  • 7NG6 · Crystal structure of mg-132 covalently bound to the main protease (3CLPRO/MPRO) of… · ALD A701 · binds HIS41, PHE140, LEU141, ASN142, GLY143, SER144, CYS145, HIS163 and 10 more

Residues it binds most

HIS 29, ALA 35, THR 31, GLY 34, GLN 27, MET 29, SER 34, LEU 22, ASP 33, CYS 27 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • NA · Sodium ion
  • EDO · 1,2-ethanediol
  • MG · Magnesium ion
  • DMS · Dimethyl sulfoxide
  • ACT · Acetate ion
  • PEG · Di(hydroxyethyl)ether
  • GOL · Glycerol
  • IPA · Isopropyl alcohol

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.