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Ligand · HYE

HYE · (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-3-hydroxy-4-(2-hydroxyethyl)-3-methyl-5-oxopyrrolidine-2-carbaldehyde

HYE, (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-3-hydroxy-4-(2-hydroxyethyl)-3-methyl-5-oxopyrrolidine-2-carbaldehyde (C15 H23 N O5, 297.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
HYE
Formula
C15 H23 N O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

HYE in 2 structures; the first of them:

  • 3HYE · Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide · HYE H300 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, GLY45, ALA46 and 7 more
  • 3HYE · Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide · HYE H300 · binds THR1, ARG19, SER20, THR21, CYS31, LYS33, GLY45, ALA46 and 7 more

Residues it binds most

THR 12, GLY 12, SER 12, ALA 12, ARG 12, LYS 12, TYR 8, CYS 4, MET 4, VAL 4 (residue and the binding sites it lines).

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