MolNFT v1 · #319861 · protein
AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase mu (P28827)
P28827: “AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase mu (P28827)”. 12 pockets (best druggability 0.84). MolNFT v1 #319861 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P28827
- Type
- protein
- Length
- 1,452 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xa73BAb1DabE4333A884D03393eAa10c3B4215494
- Molecule
- Receptor-type tyrosine-protein phosphatase mu
- UniProt
- P28827
- Pockets
- 12 · best druggability 0.84
Structure
1 distinct chain · 19% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase mu | protein | 1452 | 19% helix, 32% strand | P28827 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 949 | 0.84 | 0.85 | 93 | empty |
| 2 | 167 | 0.61 | 0.83 | 27 | empty |
| 3 | 139 | 0.60 | 0.85 | 21 | empty |
| 4 | 170 | 0.55 | 0.80 | 25 | empty |
| 5 | 228 | 0.53 | 0.77 | 22 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2V5Y · Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 2V5Y · Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 1RPM · Human receptor protein tyrosine phosphatase mu, domain 1 · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 1RPM · Human receptor protein tyrosine phosphatase mu, domain 1 · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 2C9A · Crystal structure of the mam-ig module of receptor protein tyrosine phosphatase mu · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 2C9A · Crystal structure of the MAM-Ig module of receptor protein tyrosine phosphatase mu · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 8A17 · Human PTPRM domains FN3-4, in spacegroup P3221 · an experimental structure of the same protein · chain A against B, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28827
- Elsewhere: UniProt P28827 · AlphaFold DB P28827
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