MolNFT v1 · #51383 · protein
Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain
2V5Y · Receptor-type tyrosine-protein phosphatase mu: “Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain”. X-ray diffraction, 2 ligands (NAG, NA), 1 pocket (best druggability 0.33). MolNFT v1 #51383 on GenesisL1…
- PDB
- 2V5Y
- Type
- protein
- Length
- 564 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase mu
- EC
- 3.1.3.48
- UniProt
- P28827
- Ligands
- NAG, NA
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 1 distinct chain · 1% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase mu (EC 3.1.3.48) | protein | 564 | 1% helix, 48% strand | P28827 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains A
- NA · Sodium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.33 | 0.74 | 20 | empty |
Modifications
Observed in the structure: 7 glycan, 4 disulfide (N-glycosylation, disulfide).
Compared structures
- 2V5Y · Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain · the same entry in another collection · chain A against A, TM-score 1.00
- P28827 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase mu… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28827
- Elsewhere: RCSB PDB 2V5Y · PDBe 2V5Y · UniProt P28827
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.