MolNFT v1 · #20776 · protein
Human receptor protein tyrosine phosphatase mu, domain 1
1RPM: “Human receptor protein tyrosine phosphatase mu, domain 1”. X-ray diffraction, 8 pockets (best druggability 0.44). MolNFT v1 #20776 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1RPM
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor protein tyrosine phosphatase mu
- EC
- 3.1.3.48
- UniProt
- P28827
- Pockets
- 8 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Receptor protein tyrosine phosphatase mu (EC 3.1.3.48) | protein | 278 | 36% helix, 25% strand | P28827 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.44 | 0.78 | 25 | empty |
| 2 | 125 | 0.44 | 0.77 | 24 | empty |
| 3 | 85 | 0.43 | 0.80 | 19 | empty |
| 4 | 126 | 0.40 | 0.75 | 25 | empty |
| 5 | 113 | 0.40 | 0.75 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 471 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1RPM · Human receptor protein tyrosine phosphatase mu, domain 1 · the same entry in another collection · chain A against A, TM-score 1.00
- P28827 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase mu… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28827
- Elsewhere: RCSB PDB 1RPM · PDBe 1RPM · UniProt P28827
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