MolNFT v1 · #267732 · protein
AlphaFold monomer V2.0 prediction for general negative regulator of transcription subunit 1 (P25655)
P25655: “AlphaFold monomer V2.0 prediction for general negative regulator of transcription subunit 1 (P25655)”. 18 pockets (best druggability 0.72). MolNFT v1 #267732 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P25655
- Type
- protein
- Length
- 2,108 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x4d07E6a23DeB6B95bd9b90EcB67368b7e8D3B77e
- Molecule
- General negative regulator of transcription subunit 1
- UniProt
- P25655
- Pockets
- 18 · best druggability 0.72
Structure
1 distinct chain · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General negative regulator of transcription subunit 1 | protein | 2108 | 65% helix, 1% strand | P25655 |
Pockets
18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 686 | 0.72 | 0.79 | 53 | empty |
| 2 | 705 | 0.70 | 0.77 | 50 | empty |
| 3 | 444 | 0.68 | 0.79 | 34 | empty |
| 4 | 502 | 0.68 | 0.78 | 36 | empty |
| 5 | 584 | 0.66 | 0.76 | 73 | empty |
Compared structures
- 4B8B · N-terminal domain of the yeast NOT1 · an experimental structure of the same protein · chain A against B, TM-score 0.24
- 4B8B · N-Terminal domain of the yeast Not1 · an experimental structure of the same protein · chain A against B, TM-score 0.24
- 4B8C · Nuclease module of the yeast CCR4-not complex · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 4B8C · nuclease module of the yeast Ccr4-Not complex · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 4B8A · Structure of yeast NOT1 MIF4G domain co-crystallized with CAF1 · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 4B8A · Structure of yeast NOT1 MIF4G domain co-crystallized with CAF1 · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 4B89 · MIF4G domain of the yeast Not1 · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 4B89 · MIF4G domain of the yeast NOT1 · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 4CV5 · yeast NOT1 CN9BD-CAF40 complex · an experimental structure of the same protein · chain A against A, TM-score 0.09
- 4CV5 · Yeast NOT1 CN9BD-CAF40 complex · an experimental structure of the same protein · chain A against A, TM-score 0.09
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25655
- Elsewhere: UniProt P25655 · AlphaFold DB P25655
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