MolNFT v1 · #86492 · protein

MIF4G domain of the yeast NOT1

4B89 · General negative regulator of transcription subunit 1: “MIF4G domain of the yeast NOT1”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #86492 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4B89
Type: protein
Length: 230 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: General negative regulator of transcription subunit 1
UniProt: P25655
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 66% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	General negative regulator of transcription subunit 1	protein	230	66% helix, 2% strand	P25655

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.58	0.88	15	empty
2	126	0.47	0.78	19	empty

Compared structures

4B89 · MIF4G domain of the yeast Not1 · the same entry in another collection · chain A against A, TM-score 1.00
P25655 · AlphaFold monomer V2.0 prediction for general negative regulator of transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25655
Elsewhere: RCSB PDB 4B89 · PDBe 4B89 · UniProt P25655

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