MolNFT v1 · #86493 · protein
Structure of yeast NOT1 MIF4G domain co-crystallized with CAF1
4B8A · General negative regulator of transcription subunit 1: “Structure of yeast NOT1 MIF4G domain co-crystallized with CAF1”. X-ray diffraction, 6 pockets (best druggability 0.67). MolNFT v1 #86493 on GenesisL1: 3D structure, binding…
- PDB
- 4B8A
- Type
- protein
- Length
- 484 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General negative regulator of transcription subunit 1; POLY(A) ribonuclease POP2
- EC
- 3.1.13.4
- UniProt
- P25655, P39008
- Pockets
- 6 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General negative regulator of transcription subunit 1 | protein | 232 | 63% helix, 2% strand | P25655 |
| B | POLY(A) ribonuclease POP2 (EC 3.1.13.4) | protein | 252 | 46% helix, 14% strand | P39008 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.67 | 0.83 | 38 | empty |
| 2 | 50 | 0.53 | 0.89 | 15 | empty |
| 3 | 150 | 0.47 | 0.77 | 25 | empty |
| 4 | 52 | 0.46 | 0.85 | 16 | empty |
| 5 | 72 | 0.38 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 919 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4B8A · Structure of yeast NOT1 MIF4G domain co-crystallized with CAF1 · the same entry in another collection · chain A against A, TM-score 1.00
- P25655 · AlphaFold monomer V2.0 prediction for general negative regulator of transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P39008 · AlphaFold monomer V2.0 prediction for POLY(A) ribonuclease POP2 (P39008) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25655
- Every structure of UniProt P39008
- Elsewhere: RCSB PDB 4B8A · PDBe 4B8A · UniProt P25655 · UniProt P39008
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