MolNFT v1 · #86494 · protein

N-terminal domain of the yeast NOT1

4B8B · General negative regulator of transcription subunit 1: “N-terminal domain of the yeast NOT1”. X-ray diffraction, 1 ligand (AU), 11 pockets (best druggability 0.67). MolNFT v1 #86494 on GenesisL1: 3D structure, binding sites and…

PDB: 4B8B
Type: protein
Length: 1,057 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: General negative regulator of transcription subunit 1
UniProt: P25655
Ligands: AU
Pockets: 11 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	General negative regulator of transcription subunit 1	protein	528	70% helix, 0% strand	P25655
B	General negative regulator of transcription subunit 1	protein	529	70% helix, 0% strand	P25655

Ligands and binding sites

AU · Gold ion · metal · 29 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	493	0.67	0.78	52	AU
2	142	0.67	0.88	31	empty
3	149	0.66	0.87	32	empty
4	425	0.64	0.78	46	AU
5	160	0.56	0.81	24	AU

Interfaces

1 interface between chains.

A–B · 1494 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

4B8B · N-Terminal domain of the yeast Not1 · the same entry in another collection · chain A against A, TM-score 1.00
P25655 · AlphaFold monomer V2.0 prediction for general negative regulator of transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25655
Elsewhere: RCSB PDB 4B8B · PDBe 4B8B · UniProt P25655

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.