Complex of CDC42 with the crib-pr domain of IRSP53

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 22% strand (DSSP).

Ligands and binding sites

• GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
• MG · Magnesium ion · metal · 2 copies · chains A
• PE4 · 2-{2-[2-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1160 Ų buried · 15 hydrogen bonds · protein-protein

Compared structures

• 4JS0 · Complex of Cdc42 with the CRIB-PR domain of IRSp53 · the same entry in another collection · chain A against A, TM-score 1.00
• P60953 · AlphaFold monomer V2.0 prediction for cell division control protein 42 homolog (P60953) · a predicted model of the same protein · chain A against A, TM-score 0.99
• Q9UQB8 · AlphaFold monomer V2.0 prediction for brain-specific angiogenesis inhibitor 1-associated… · a predicted model of the same protein · chain B against A, TM-score 0.33

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P60953
• Every structure of UniProt Q9UQB8
• Elsewhere: RCSB PDB 4JS0 · PDBe 4JS0 · UniProt P60953 · UniProt Q9UQB8