UniProt Q9UQB8
Insulin receptor substrate protein of 53 kDa, peptide (IRSp53) (Q9UQB8)
Insulin receptor substrate protein of 53 kDa, peptide (IRSp53) (UniProt Q9UQB8), EC 3.1.3.16: 18 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 29 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9UQB8
- Protein
- Insulin receptor substrate protein of 53 kDa, peptide (IRSp53)
- EC
- 3.1.3.16
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 29 · 4 records with a druggable one
Structures
19 records of Q9UQB8 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WDZ | Crystal structure of RCB domain of IRSp53 | x-ray diffraction | A, B | — | — |
| 1WDZ | Crystal structure of rcb domain of IRSP53 | x-ray diffraction | A, B | — | — |
| 1Y2O | Structure of N-terminal domain IRSp53/BAIAP2 | x-ray diffraction | A, B | — | — |
| 1Y2O | Structure of N-terminal domain IRSP53/BAIAP2 | x-ray diffraction | A, B | — | — |
| 2YKT | Crystal structure of the I-BAR domain of IRSp53 (BAIAP2) in complex with an EHEC derived Tir peptide | x-ray diffraction | A | — | — |
| 2YKT | Crystal structure of the I-bar domain of IRSP53 (BAIAP2) in complex with an ehec derived tir peptide | x-ray diffraction | A | — | — |
| 3RNJ | Crystal structure of the SH3 domain from IRSp53 (BAIAP2) | x-ray diffraction | A | — | — |
| 3RNJ | Crystal structure of the SH3 domain from IRSP53 (BAIAP2) | x-ray diffraction | A | — | — |
| 4JS0 | Complex of Cdc42 with the CRIB-PR domain of IRSp53 | x-ray diffraction | B | — | — |
| 4JS0 | Complex of CDC42 with the crib-pr domain of IRSP53 | x-ray diffraction | B | — | — |
| 6BD2 | Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366 | x-ray diffraction | C | — | 6 (best 0.62) |
| 6BD2 | Complex of 14-3-3 theta with an IRSP53 peptide doubly-phosphorylated at T340 and S366 | x-ray diffraction | C | — | — |
| 6BQT | Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360 | x-ray diffraction | C, F, I, L | — | 14 (best 0.77) |
| 6BQT | Complex of 14-3-3 theta with an IRSP53 peptide doubly-phosphorylated at T340 and T360 | x-ray diffraction | C, F, I, L | — | — |
| 6ZEG | Structure of PP1-IRSp53 chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)] bound to Phactr1… | x-ray diffraction | A, B | MN, PO4, 16P | 4 (best 0.69) |
| 6ZEG | Structure of PP1-IRSP53 chimera [PP1(7-304) + linker (G/S)X9 + IRSP53(449-465)] bound to PHACTR1… | x-ray diffraction | A, B | MN, PO4, 16P | — |
| 6ZEI | Structure of PP1-IRSp53 S455E chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)] bound to… | x-ray diffraction | A, B | MN, PO4 | 5 (best 0.68) |
| 6ZEI | Structure of PP1-IRSP53 S455E chimera [PP1(7-304) + linker (G/S)X9 + IRSP53(449-465)] bound to… | x-ray diffraction | A, B | MN, PO4 | — |
| Q9UQB8 | AlphaFold monomer V2.0 prediction for brain-specific angiogenesis inhibitor 1-associated protein 2… | predicted | A | — | — |
Ligands
Experiment against prediction
- 6ZEI chain A against the predicted model P62136: TM-score 0.99, RMSD 0.96 Å
- 6ZEI chain A against the predicted model P62136: TM-score 0.99, RMSD 0.96 Å
- 6ZEI chain B against the predicted model P62136: TM-score 0.98, RMSD 1.03 Å
- 6ZEI chain B against the predicted model P62136: TM-score 0.98, RMSD 1.03 Å
- 6ZEG chain B against the predicted model P62136: TM-score 0.98, RMSD 1.10 Å
- 6ZEG chain B against the predicted model P62136: TM-score 0.98, RMSD 1.10 Å
- 6ZEG chain A against the predicted model P62136: TM-score 0.98, RMSD 1.03 Å
- 6ZEG chain A against the predicted model P62136: TM-score 0.98, RMSD 1.03 Å
- 1WDZ chain B against the predicted model Q9UQB8: TM-score 0.97, RMSD 0.94 Å
- 1WDZ chain B against the predicted model Q9UQB8: TM-score 0.97, RMSD 0.94 Å
Elsewhere
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