MolNFT v1 · #26067 · protein
Crystal structure of rcb domain of IRSP53
1WDZ · Insulin receptor substrate P53: “Crystal structure of rcb domain of IRSP53”. X-ray diffraction, 5 pockets (best druggability 0.87). MolNFT v1 #26067 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1WDZ
- Type
- protein
- Length
- 453 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor substrate P53
- UniProt
- Q9UQB8
- Pockets
- 5 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor substrate P53 | protein | 231 | 94% helix, 0% strand | Q9UQB8 |
| B | Insulin receptor substrate P53 | protein | 222 | 92% helix, 0% strand | Q9UQB8 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 354 | 0.87 | 0.96 | 44 | empty |
| 2 | 58 | 0.49 | 0.85 | 14 | empty |
| 3 | 50 | 0.46 | 0.85 | 11 | empty |
| 4 | 62 | 0.32 | 0.76 | 14 | empty |
| 5 | 60 | 0.31 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 2854 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UQB8
- Elsewhere: RCSB PDB 1WDZ · PDBe 1WDZ · UniProt Q9UQB8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.