Research workbench
1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
Analyse 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HI9
- Type
- protein
- Length
- 240 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrin-linked protein kinase; Lim and senescent cell antigen-like-containing domain…
- EC
- 2.7.11.1
- UniProt
- Q13418, P48059
- Ligands
- ZN, IOD, PO4
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin-linked protein kinase (EC 2.7.11.1) | protein | 168 | 48% helix, 1% strand | Q13418 |
| B | Lim and senescent cell antigen-like-containing domain protein 1 | protein | 72 | 14% helix, 26% strand | P48059 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains B
- IOD · Iodide ion · ion · 10 copies · chains A, B
- PO4 · Phosphate ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.33 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 974 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4HI9 · 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1… · the same entry in another collection · chain B against B, TM-score 1.00
- Q13418 · AlphaFold monomer V2.0 prediction for integrin-linked protein kinase (Q13418) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P48059 · AlphaFold monomer V2.0 prediction for lim and senescent cell antigen- like-containing… · a predicted model of the same protein · chain B against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13418
- Every structure of UniProt P48059
- Elsewhere: RCSB PDB 4HI9 · PDBe 4HI9 · UniProt Q13418 · UniProt P48059
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