UniProt Q13418
Integrin-linked protein kinase (Q13418)
Integrin-linked protein kinase (UniProt Q13418), EC 2.7.11.1: 18 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q13418
- Protein
- Integrin-linked protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 22 · 6 records with a druggable one
Structures
19 records of Q13418 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KBX | Solution structure of ILK-PINCH complex | solution nmr | A | — | 4 (best 0.70) |
| 2KBX | Solution structure of ilk-pinch complex | solution nmr | A | — | — |
| 3F6Q | Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain | x-ray diffraction | A | IOD, PO4 | 1 (best 0.30) |
| 3F6Q | Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain | x-ray diffraction | A | — | — |
| 3IXE | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain… | x-ray diffraction | A | — | — |
| 3IXE | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain… | x-ray diffraction | A | — | — |
| 3KMU | Crystal structure of the ILK/alpha-parvin core complex (apo) | x-ray diffraction | A | — | 3 (best 0.81) |
| 3KMU | Crystal structure of the ILK/ALPHA-parvin core complex (apo) | x-ray diffraction | A | — | — |
| 3KMW | Crystal structure of the ILK/alpha-parvin core complex (MgATP) | x-ray diffraction | A | MG, ATP | 2 (best 0.77) |
| 3KMW | Crystal structure of the ILK/ALPHA-parvin core complex (mgatp) | x-ray diffraction | A | — | — |
| 3REP | Crystal structure of the ILK/alpha-parvin core complex (MnATP) | x-ray diffraction | A | MN, ATP | 3 (best 0.77) |
| 3REP | Crystal structure of the ILK/ALPHA-parvin core complex (mnatp) | x-ray diffraction | A | — | — |
| 4HI8 | Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain… | x-ray diffraction | A | PO4 | 1 (best 0.31) |
| 4HI8 | Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain… | x-ray diffraction | A | — | — |
| 4HI9 | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain… | x-ray diffraction | A | PO4, IOD | 1 (best 0.33) |
| 4HI9 | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain… | x-ray diffraction | A | — | — |
| 6MIB | Crystal structure of the ILK ATP-binding deficient mutant (L207W)/alpha-parvin core complex | x-ray diffraction | A | — | 2 (best 0.81) |
| 6MIB | Crystal structure of the ilk ATP-binding deficient mutant (L207W) /alpha-parvin core complex | x-ray diffraction | A | — | — |
| Q13418 | AlphaFold monomer V2.0 prediction for integrin-linked protein kinase (Q13418) | predicted | A | — | 5 (best 0.75) |
Ligands
Experiment against prediction
- 4HI9 chain A against the predicted model Q13418: TM-score 0.98, RMSD 1.09 Å
- 4HI9 chain A against the predicted model Q13418: TM-score 0.98, RMSD 1.09 Å
- 3F6Q chain A against the predicted model Q13418: TM-score 0.98, RMSD 1.10 Å
- 3F6Q chain A against the predicted model Q13418: TM-score 0.98, RMSD 1.10 Å
- 4HI8 chain A against the predicted model Q13418: TM-score 0.97, RMSD 1.28 Å
- 4HI8 chain A against the predicted model Q13418: TM-score 0.97, RMSD 1.28 Å
- 3KMU chain A against the predicted model Q13418: TM-score 0.97, RMSD 1.36 Å
- 3KMU chain A against the predicted model Q13418: TM-score 0.97, RMSD 1.36 Å
- 3REP chain A against the predicted model Q13418: TM-score 0.97, RMSD 1.42 Å
- 3REP chain A against the predicted model Q13418: TM-score 0.97, RMSD 1.42 Å
Elsewhere
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