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Crystal structure of ligand free human sting

Analyse Crystal structure of ligand free human sting in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4EMU
Type: protein
Length: 350 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transmembrane protein 173
UniProt: Q86WV6
Ligands: CA
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transmembrane protein 173	protein	175	45% helix, 21% strand	Q86WV6

Ligands and binding sites

CA · Calcium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	824	0.69	0.75	63	empty
2	53	0.26	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 854 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

4EMU · Crystal structure of ligand free human STING · the same entry in another collection · chain B against B, TM-score 1.00
Q86WV6 · AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (Q86WV6) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86WV6
Elsewhere: RCSB PDB 4EMU · PDBe 4EMU · UniProt Q86WV6

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