UniProt Q86WV6
Stimulator of interferon genes protein (Q86WV6)
Stimulator of interferon genes protein (UniProt Q86WV6): 59 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q86WV6
- Protein
- Stimulator of interferon genes protein
- Experimental structures
- 59
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 14 · 2 records with a druggable one
Structures
60 records of Q86WV6 in the MolNFT archive: 59 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4EF4 | Crystal structure of STING CTD complex with c-di-GMP | x-ray diffraction | A, B | — | — |
| 4EF4 | Crystal structure of sting ctd complex with C-di-gmp | x-ray diffraction | A, B | — | — |
| 4EF5 | Crystal structure of STING CTD | x-ray diffraction | A | — | — |
| 4EF5 | Crystal structure of sting ctd | x-ray diffraction | A | — | — |
| 4EMT | Crystal Structure of human STING bound to c-di-GMP | x-ray diffraction | A, B | — | — |
| 4EMT | Crystal structure of human sting bound to C-di-gmp | x-ray diffraction | A, B | — | — |
| 4EMU | Crystal structure of ligand free human STING | x-ray diffraction | A, B | — | — |
| 4EMU | Crystal structure of ligand free human sting | x-ray diffraction | A, B | — | — |
| 4F5D | ERIS/STING in complex with ligand | x-ray diffraction | A, B | — | — |
| 4F5D | ERIS/STING in complex with ligand | x-ray diffraction | A, B | — | — |
| 4F5E | Crystal structure of ERIS/STING | x-ray diffraction | A | — | — |
| 4F5E | Crystal structure of ERIS/STING | x-ray diffraction | A | — | — |
| 4F5W | Crystal structure of ligand free human STING CTD | x-ray diffraction | A | — | — |
| 4F5W | Crystal structure of ligand free human sting ctd | x-ray diffraction | A | — | — |
| 4F5Y | Crystal structure of human STING CTD complex with C-di-GMP | x-ray diffraction | A, B | — | — |
| 4F5Y | Crystal structure of human sting ctd complex with C-di-gmp | x-ray diffraction | A, B | — | — |
| 4F9E | Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING | x-ray diffraction | A | — | — |
| 4F9E | Cyclic di-gmp sensing via the innate immune signaling protein sting | x-ray diffraction | A | — | — |
| 4F9G | Crystal structure of STING complex with Cyclic di-GMP. | x-ray diffraction | A, C | — | — |
| 4F9G | Crystal structure of sting complex with cyclic di-gmp. | x-ray diffraction | A, C | — | — |
| 4KSY | Crystal structure of STING in complex with cGAMP | x-ray diffraction | A | — | — |
| 4KSY | Crystal structure of sting in complex with cgamp | x-ray diffraction | A | — | — |
| 4LOH | Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(3',5')p] | x-ray diffraction | A, B | — | — |
| 4LOH | Crystal structure of HSTING(H232) in complex with C[G(2',5')PA(3',5') P] | x-ray diffraction | A, B | — | — |
| 4LOI | Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(2',5')p] | x-ray diffraction | A, B | — | — |
| 4LOI | Crystal structure of HSTING(H232) in complex with C[G(2',5')PA(2',5') P] | x-ray diffraction | A, B | — | — |
| 4QXO | Crystal structure of hSTING(group2) in complex with DMXAA | x-ray diffraction | A | — | — |
| 4QXO | Crystal structure of HSTING(GROUP2) in complex with dmxaa | x-ray diffraction | A | — | — |
| 4QXP | Crystal structure of hSTING(G230I) in complex with DMXAA | x-ray diffraction | A, B | — | — |
| 4QXP | Crystal structure of HSTING(G230I) in complex with dmxaa | x-ray diffraction | A, B | — | — |
| 4QXQ | Crystal structure of hSTING(S162A/Q266I) in complex with DMXAA | x-ray diffraction | A, B | — | — |
| 4QXQ | Crystal structure of HSTING(S162A/Q266I) in complex with dmxaa | x-ray diffraction | A, B | — | — |
| 4QXR | Crystal structure of hSTING(S162A/G230I/Q266I) in complex with DMXAA | x-ray diffraction | A, B | — | — |
| 4QXR | Crystal structure of HSTING(S162A/G230I/Q266I) in complex with dmxaa | x-ray diffraction | A, B | — | — |
| 5BQX | Crystal structure of human STING in complex with 3'2'-cGAMP | x-ray diffraction | A | 4UR | 1 (best 0.41) |
| 5BQX | Crystal structure of human sting in complex with 3'2'-cgamp | x-ray diffraction | A | — | — |
| 5JEJ | Phosphorylated sting in complex with irf-3 ctd | x-ray diffraction | C, D, E | — | — |
| 6CFF | Stimulator of interferon genes human | x-ray diffraction | A | 2BA | — |
| 6CY7 | Human stimulator of interferon genes | x-ray diffraction | A | 2BA | — |
| 6DNK | Human Stimulator of Interferon Genes | x-ray diffraction | A | 1SY | 1 (best 0.36) |
| 6DNK | Human stimulator of interferon genes | x-ray diffraction | A | 1SY | — |
| 6MX0 | Crystal structure of human sting apoprotein (G230A, H232R, R293Q) | x-ray diffraction | A, B | CA | — |
| 6MX3 | Crystal structure of human sting (G230A, H232R, R293Q) in complex with compound 1 | x-ray diffraction | A, B | K5P, CA | — |
| 6MXE | Crystal structure of human sting (G230A, H232R, R293Q) in complex with compound 18 | x-ray diffraction | A, B | K5S, CA | — |
| 6O8B | Crystal structure of sting ctd in complex with TBK1 | x-ray diffraction | D, E | — | — |
| 6O8C | Crystal structure of STING CTT in complex with TBK1 | x-ray diffraction | D, E | — | — |
| 6O8C | Crystal structure of sting ctt in complex with TBK1 | x-ray diffraction | D, E | — | — |
| 6XF3 | Crystal structure of sting in complex with E7766 | x-ray diffraction | A, B | V5V | — |
| 6XF4 | Crystal structure of sting ref variant in complex with E7766 | x-ray diffraction | A, B | V5V | — |
| 6Y99 | Hsting mutant R232K in complex with 2',3'-cgamp | x-ray diffraction | A | 1SY | — |
| 6YWA | Human ref sting in complex with 3',3'-C-[2'FDAMP-2'FDAM(PS)] | x-ray diffraction | A, B | PWB | — |
| 7MHC | Structure of human sting in complex with mk-1454 | x-ray diffraction | A | ZEV | — |
| 7OB3 | Hsting in complex with 3',3'-C-di-araamp | x-ray diffraction | A | V7E | — |
| 7SII | Human sting bound to both cgamp and 1-[(2-chloro-6-fluorophenyl)… | electron microscopy | A, B, C, D | 9IM, 1SY | — |
| 7T9V | Crystal structure of hSTING with the agonist, SHR171032 | x-ray diffraction | A, B | CA, GC0 | — |
| 8A2J | human STING in complex with 2'-3'-cyclic-GMP-7-deaza(4-biphenylyl)-AMP | x-ray diffraction | A, B | KWO | 1 (best 0.85) |
| 8A2K | human STING in complex with 2'-3'-cyclic-GMP-7-deaza(4-[(2-naphthyloxy)methyl]phenyl)-AMP | x-ray diffraction | A, B | KXD | — |
| 8GSZ | Structure of STING SAVI-related mutant V147L | electron microscopy | A, B | — | 7 (best 0.80) |
| 8STI | human STING with agonist XMT-1616 | x-ray diffraction | A | WX8 | — |
| Q86WV6 | AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (Q86WV6) | predicted | A | — | 4 (best 0.39) |
Ligands
- 1SY · cGAMP · in 4 records
- CA · Calcium ion · in 4 records
- 2BA · (2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-D:3', 2'-J][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5, 10,12-tetrol 5,12-dioxide · in 2 records
- V5V · (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4, 6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7, 12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21, 23,25-nonaene 34,39-dioxide (non-preferred name) · in 2 records
- 4UR · 3'2'-cGAMP · in 1 record
- 9IM · 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide · in 1 record
- GC0 · (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide · in 1 record
- K5P · (3S,4S)-2-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid · in 1 record
- K5S · [(3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]acetic acid · in 1 record
- KWO · 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-[4-azanyl-5-(4-phenylphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one · in 1 record
- KXD · 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-[4-azanyl-5-[4-(naphthalen-1-yloxymethyl)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-3~{H}-purin-6-one · in 1 record
- PWB · 3',3'-C-[2'fdamp-2'fdam(ps)] · in 1 record
- V7E · 3',3'-C-di-araamp · in 1 record
- WX8 · 3-[(2E)-4-{5-carbamoyl-2-[(4-ethyl-2-methyl-1,3-oxazole-5-carbonyl)amino]-7-(3-hydroxypropoxy)-1H-benzimidazol-1-yl}but-2-en-1-yl]-2-[(4-ethyl-2-methyl-1,3-oxazole-5-carbonyl)amino]-3H-imidazo[4,5-b]pyridine-6-carboxamide · in 1 record
- ZEV · (2r,5r,7r,8s,10r,12ar,14r,15s,15ar,16r)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H, 12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-L][1, 3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione · in 1 record
Experiment against prediction
- 8A2K chain B against the predicted model Q86WV6: TM-score 0.97, RMSD 0.93 Å
- 6CFF chain A against the predicted model Q86WV6: TM-score 0.97, RMSD 0.92 Å
- 6CY7 chain A against the predicted model Q86WV6: TM-score 0.97, RMSD 0.95 Å
- 6DNK chain A against the predicted model Q86WV6: TM-score 0.97, RMSD 0.98 Å
- 6DNK chain A against the predicted model Q86WV6: TM-score 0.97, RMSD 0.98 Å
- 6Y99 chain A against the predicted model Q86WV6: TM-score 0.97, RMSD 1.04 Å
- 4LOI chain A against the predicted model Q86WV6: TM-score 0.96, RMSD 1.11 Å
- 4LOI chain A against the predicted model Q86WV6: TM-score 0.96, RMSD 1.11 Å
- 8GSZ chain A against the predicted model Q86WV6: TM-score 0.96, RMSD 1.37 Å
- 8GSZ chain B against the predicted model Q86WV6: TM-score 0.96, RMSD 1.37 Å
Elsewhere
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