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Ligand · 1SY

1SY · cGAMP

1SY, cGAMP (C20 H24 N10 O13 P2, 674.4 g/mol), in the MolNFT structures on GenesisL1: bound in 15 records (12 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
1SY
Formula
C20 H24 N10 O13 P2
Class
ligand
Structures
15
PDB entries
12

Binding sites

1SY in 15 structures; the first of them:

  • 5GRM · Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and… · 1SY B401 · binds SER162, TYR163, GLY166, TYR167, ARG238, TYR240, GLU260, THR263 and 10 more
  • 6DNK · Human Stimulator of Interferon Genes · 1SY A401 · binds SER162, TYR163, GLY166, TYR167, ARG232, ARG238, VAL239, TYR240 and 3 more
  • 6WT7 · Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP · 1SY A501 · binds GLY182, TYR183, GLY186, TYR187, ALA251, ILE253, ARG256, GLN257 and 5 more
  • 7BUQ · mcGAS bound with 23-cGAMP · 1SY A602 · binds ILE206, ASP213, MET215, PRO292, ASP307, ILE309, VAL348, LYS350 and 8 more
  • 7XQ2 · Structure of hSLC19A1+2'3'-cGAMP · 1SY A601 · binds TYR149, GLN150, ARG157, TRP274, LYS328, PRO381, THR384, PHE385 and 4 more
  • 5VDP · Human cyclic gmp-AMP synthase (cgas) in complex with 2',3'-cgamp · 1SY A605 · binds ASP227, GLY303, GLY304, SER305, PRO306, ALA307, ASP319, THR321 and 8 more
  • 6A06 · Structure of psting complex · 1SY B403 · binds SER162, TYR163, GLY166, TYR167, ILE235, ARG238, TYR240, GLU260 and 12 more
  • 6DNK · Human stimulator of interferon genes · 1SY A401 · binds SER162, TYR163, GLY166, TYR167, ARG232, ARG238, VAL239, TYR240 and 2 more
  • 6MJX · Human cgas catalytic domain bound with cgamp · 1SY A601 · binds ASP227, LYS301, GLY304, SER305, PRO306, ALA307, ASP319, THR321 and 4 more
  • 6NT7 · Cryo-EM structure of full-length chicken sting in the cgamp-bound dimeric state · 1SY A401 · binds SER167, TYR168, GLY171, TYR172, ARG243, VAL244, TYR245, GLU265 and 11 more
  • 6NT8 · Cryo-EM structure of full-length chicken sting in the cgamp-bound tetrameric state · 1SY A401 · binds SER167, TYR168, GLY171, TYR172, ARG243, VAL244, TYR245, GLU265 and 10 more
  • 6WT7 · Structure of a metazoan tir-sting receptor from C. gigas in complex with 2',3'-cgamp · 1SY A501 · binds TYR183, GLY186, TYR187, ILE253, ARG256, GLN257, TYR258, GLY281 and 1 more
  • 6Y99 · Hsting mutant R232K in complex with 2',3'-cgamp · 1SY A401 · binds SER162, GLY166, TYR167, ILE235, ARG238, TYR240, THR263, PRO264 and 1 more
  • 7BUQ · Mcgas bound with 23-cgamp · 1SY A602 · binds ILE206, ASP213, MET215, ASP307, ILE309, VAL348, LYS350, ARG364 and 4 more
  • 7SII · Human sting bound to both cgamp and 1-[(2-chloro-6-fluorophenyl)… · 1SY B401 · binds SER162, TYR163, GLY166, TYR167, ARG238, VAL239, TYR240, THR263 and 11 more

Residues it binds most

TYR 20, SER 18, ARG 21, GLY 16, THR 12, VAL 15, PRO 16, ILE 14, ASP 7, LYS 9 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • SO4 · Sulfate ion
  • 9IM · 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide

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