MolNFT v1 · #168850 · protein
Structure of a metazoan tir-sting receptor from C. gigas in complex with 2',3'-cgamp
6WT7 · Metazoan tir-sting fusion: “Structure of a metazoan tir-sting receptor from C. gigas in complex with 2',3'-cgamp”. X-ray diffraction, 1 ligand (1SY), 4 pockets (best druggability 0.41). MolNFT v1 #168850 on GenesisL1: 3D structure…
- PDB
- 6WT7
- Type
- protein
- Length
- 331 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metazoan tir-sting fusion
- Ligands
- 1SY
- Pockets
- 4 · best druggability 0.41
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metazoan tir-sting fusion | protein | 331 | 40% helix, 21% strand | — |
Ligands and binding sites
- 1SY · cGAMP · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.41 | 0.80 | 17 | empty |
| 2 | 113 | 0.35 | 0.73 | 21 | empty |
| 3 | 59 | 0.33 | 0.77 | 15 | empty |
| 4 | 84 | 0.32 | 0.73 | 18 | empty |
Compared structures
- 6WT7 · Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6WT7 · PDBe 6WT7
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