MolNFT v1 · #158418 · protein
Cryo-EM structure of full-length chicken sting in the cgamp-bound tetrameric state
6NT8 · Stimulator of interferon genes protein: “Cryo-EM structure of full-length chicken sting in the cgamp-bound tetrameric state”. Electron microscopy, 1 ligand (1SY), 20 pockets (best druggability 0.84). MolNFT v1 #158418 on GenesisL1…
- PDB
- 6NT8
- Type
- protein
- Length
- 1,176 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulator of interferon genes protein
- UniProt
- A0A1D5P7Q9
- Ligands
- 1SY
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, E | Stimulator of interferon genes protein | protein | 294 | 54% helix, 14% strand | A0A1D5P7Q9 |
Ligands and binding sites
- 1SY · cGAMP · ligand · 2 copies · chains A, B, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 465 | 0.84 | 0.91 | 46 | 1SY |
| 2 | 461 | 0.83 | 0.90 | 45 | 1SY |
| 3 | 940 | 0.80 | 0.82 | 80 | empty |
| 4 | 952 | 0.79 | 0.81 | 85 | empty |
| 5 | 600 | 0.71 | 0.79 | 61 | empty |
Interfaces
6 interfaces between chains.
- D–E · 5013 Ų buried · 39 hydrogen bonds · protein-protein
- A–B · 5013 Ų buried · 39 hydrogen bonds · protein-protein
- A–D · 79 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 55 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 53 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6NT8 · Cryo-EM structure of full-length chicken STING in the cGAMP-bound tetrameric state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1D5P7Q9
- Elsewhere: RCSB PDB 6NT8 · PDBe 6NT8 · UniProt A0A1D5P7Q9
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