MolNFT v1 · #158417 · protein

Cryo-EM structure of full-length chicken sting in the cgamp-bound dimeric state

6NT7 · Stimulator of interferon genes protein: “Cryo-EM structure of full-length chicken sting in the cgamp-bound dimeric state”. Electron microscopy, 1 ligand (1SY), 10 pockets (best druggability 0.83). MolNFT v1 #158417 on GenesisL1: 3D…

PDB: 6NT7
Type: protein
Length: 588 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stimulator of interferon genes protein
UniProt: A0A1D5P7Q9
Ligands: 1SY
Pockets: 10 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 54% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Stimulator of interferon genes protein	protein	294	54% helix, 14% strand	A0A1D5P7Q9

Ligands and binding sites

1SY · cGAMP · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	469	0.83	0.90	43	1SY
2	1062	0.80	0.82	94	empty
3	569	0.70	0.79	59	empty
4	89	0.46	0.80	16	empty
5	118	0.46	0.78	22	empty

Interfaces

1 interface between chains.

A–B · 5016 Å² buried · 39 hydrogen bonds · protein-protein

Compared structures

6NT7 · Cryo-EM structure of full-length chicken STING in the cGAMP-bound dimeric state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1D5P7Q9
Elsewhere: RCSB PDB 6NT7 · PDBe 6NT7 · UniProt A0A1D5P7Q9

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