GRB2 SH2 DOMAIN/CD28-derived peptide complex

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 28% strand (DSSP).

Ligands and binding sites

• CD · Cadmium ion · metal · chains A
• ACY · Acetic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 464 Ų buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

• 3WA4 · Grb2 SH2 domain/CD28-derived peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
• P62993 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 2 (P62993) · a predicted model of the same protein · chain A against A, TM-score 0.98
• P10747 · AlphaFold monomer V2.0 prediction for T-cell-specific surface glycoprotein CD28 (P10747) · a predicted model of the same protein · chain B against A, TM-score 0.62

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P62993
• Every structure of UniProt P10747
• Elsewhere: RCSB PDB 3WA4 · PDBe 3WA4 · UniProt P62993 · UniProt P10747