UniProt P62993
P62993
P62993 (UniProt P62993): 88 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P62993
- Experimental structures
- 88
- Predicted models
- 1
- Ligands
- 8
Structures
89 records of P62993 in the MolNFT archive: 88 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AZE | NMR structure of the complex between the C32S-Y7V mutant of the NSH3 domain of GRB2 with a peptide… | solution nmr | A | — | — |
| 1AZE | NMR structure of the complex between the C32S-Y7V mutant of the NSH3 domain of GRB2 with a peptide… | solution nmr | A | — | — |
| 1BMB | GRB2-SH2 domain in complex with KPFY*VNVEF (PKF270-974) | x-ray diffraction | A | — | — |
| 1BMB | GRB2-SH2 domain in complex with KPFY*VNVEF (PKF270-974) | x-ray diffraction | A | — | — |
| 1CJ1 | Growth factor receptor binding protein SH2 domain (human) complexed with a phosphotyrosyl derivative | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1CJ1 | Growth factor receptor binding protein SH2 domain (human) complexed with a phosphotyrosyl derivative | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1FHS | The three-dimensional solution structure of the src homology domain-2 of the growth factor receptor… | solution nmr | A | — | — |
| 1FHS | The three-dimensional solution structure of the src homology domain-2 of the growth factor receptor… | solution nmr | A | — | — |
| 1GCQ | Crystal structure of vav and GRB2 SH3 domains | x-ray diffraction | A, B | — | — |
| 1GCQ | Crystal structure of vav and GRB2 SH3 domains | x-ray diffraction | A, B | — | — |
| 1GFC | Solution structure and ligand-binding site of the C-terminal SH3 domain of GRB2 | solution nmr | A | — | — |
| 1GFC | Solution structure and ligand-binding site of the C-terminal SH3 domain of GRB2 | solution nmr | A | — | — |
| 1GFD | Solution structure and ligand-binding site of the C-terminal SH3 domain of GRB2 | solution nmr | A | — | — |
| 1GFD | Solution structure and ligand-binding site of the C-terminal SH3 domain of GRB2 | solution nmr | A | — | — |
| 1GHU | NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures | solution nmr | A | — | — |
| 1GHU | NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures | solution nmr | A | — | — |
| 1GRI | GRB2 | x-ray diffraction | A, B | — | — |
| 1GRI | GRB2 | x-ray diffraction | A, B | — | — |
| 1IO6 | Growth factor receptor-bound protein 2 (GRB2) C-terminal SH3 domain complexed with a ligand peptide… | solution nmr | A | — | — |
| 1IO6 | Growth factor receptor-bound protein 2 (GRB2) C-terminal SH3 domain complexed with a ligand peptide… | solution nmr | A | — | — |
| 1JYR | Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide | x-ray diffraction | A | — | — |
| 1JYR | Xray structure of GRB2 SH2 domain complexed with a phosphorylated peptide | x-ray diffraction | A | — | — |
| 1JYU | Xray Structure of Grb2 SH2 Domain | x-ray diffraction | A | — | — |
| 1JYU | Xray structure of GRB2 SH2 domain | x-ray diffraction | A | — | — |
| 1QG1 | Growth factor receptor binding protein SH2 domain complexed with an shc-derived peptide | solution nmr | E | — | — |
| 1QG1 | Growth factor receptor binding protein SH2 domain complexed with an shc-derived peptide | solution nmr | E | — | — |
| 1X0N | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor | solution nmr | A | — | — |
| 1X0N | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor | solution nmr | A | — | — |
| 2AOA | Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2… | x-ray diffraction | A, B | — | — |
| 2AOA | Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the GRB2 SH2… | x-ray diffraction | A, B | — | — |
| 2AOB | Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2… | x-ray diffraction | A, B, C, D | — | — |
| 2AOB | Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the GRB2 SH2… | x-ray diffraction | A, B, C, D | — | — |
| 2H5K | Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived… | x-ray diffraction | A, B | — | — |
| 2H5K | Crystal structure of complex between the domain-swapped dimeric GRB2 SH2 domain and shc-derived… | x-ray diffraction | A, B | — | — |
| 2HUW | X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived… | x-ray diffraction | A, B | — | — |
| 2HUW | X-ray crystal structure of the GRB2 SH2 domain complexed to a constrained and cyclopropane-derived… | x-ray diffraction | A, B | — | — |
| 2VVK | Grb2 SH3C (1) | x-ray diffraction | A | — | — |
| 2VVK | GRB2 SH3C (1) | x-ray diffraction | A | — | — |
| 2VWF | Grb2 SH3C (2) | x-ray diffraction | A | — | — |
| 2VWF | GRB2 SH3C (2) | x-ray diffraction | A | — | — |
| 2W0Z | Grb2 SH3C (3) | x-ray diffraction | A | — | — |
| 2W0Z | GRB2 SH3C (3) | x-ray diffraction | A | — | — |
| 3C7I | X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN. | x-ray diffraction | A | — | — |
| 3C7I | X-ray crystal structure of the complex between the GRB2-SH2 domain and a flexible ligand, fptvn. | x-ray diffraction | A | — | — |
| 3IMD | Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic | x-ray diffraction | A, B | — | — |
| 3IMD | Crystal structure of the GRB2 SH2 domain in complex with a flexible ac-py-Q-N-NH2 tripeptide mimic | x-ray diffraction | A, B | — | — |
| 3IMJ | Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained… | x-ray diffraction | A, B | — | — |
| 3IMJ | Crystal structure of the GRB2 SH2 domain in complex with a cyclopropyl-constrained… | x-ray diffraction | A, B | — | — |
| 3IN7 | Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2… | x-ray diffraction | A, C | — | — |
| 3IN7 | Crystal structure of the GRB2 SH2 domain in complex with a cyclopropyl-constrained ac-py-Q-N-NH2… | x-ray diffraction | A, C | — | — |
| 3IN8 | Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide… | x-ray diffraction | A | — | — |
| 3IN8 | Crystal structure of the GRB2 SH2 domain in complex with a flexible ac-ptyr-ile-asn-NH2 tripeptide… | x-ray diffraction | A | — | — |
| 3KFJ | Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic | x-ray diffraction | A | — | — |
| 3KFJ | Crystal structure of the GRB2 SH2 domain in complex with a flexible ac-py-E-N-NH2 tripeptide mimic | x-ray diffraction | A | — | — |
| 3MXC | Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their… | x-ray diffraction | A | — | — |
| 3MXC | Structures of GRB2-SH2 domain and aicd peptide complexes reveal a conformational switch and their… | x-ray diffraction | A | — | — |
| 3MXY | Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their… | x-ray diffraction | A | — | — |
| 3MXY | Structures of GRB2-SH2 domain and aicd peptide complexes reveal a conformational switch and their… | x-ray diffraction | A | — | — |
| 3N7Y | Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having… | x-ray diffraction | A, B, C | — | — |
| 3N7Y | Crystal structure of the GRB2 SH2 domain in complex with a 20-membered macrocyclic ligand having… | x-ray diffraction | A, B, C | — | — |
29 records more on the page itself.
Ligands
- ACE · Acetyl group · in 2 records
- CA · Calcium ion · in 2 records
- CL · Chloride ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- NA · Sodium ion · in 1 record
- PRA · 3-phenylpropylamine · in 1 record
- U67 · 4-methylpentan-1-amine · in 1 record
- ZLY · (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid · in 1 record
Experiment against prediction
- 3WA4 chain A against the predicted model P62993: TM-score 0.98, RMSD 0.55 Å
- 3WA4 chain A against the predicted model P62993: TM-score 0.98, RMSD 0.55 Å
- 1CJ1 chain A against the predicted model P62993: TM-score 0.97, RMSD 0.61 Å
- 1CJ1 chain A against the predicted model P62993: TM-score 0.97, RMSD 0.61 Å
- 2HUW chain B against the predicted model P62993: TM-score 0.97, RMSD 0.85 Å
- 2HUW chain B against the predicted model P62993: TM-score 0.97, RMSD 0.85 Å
- 1GCQ chain A against the predicted model P62993: TM-score 0.96, RMSD 0.56 Å
- 1GCQ chain A against the predicted model P62993: TM-score 0.96, RMSD 0.56 Å
- 3KFJ chain A against the predicted model P62993: TM-score 0.96, RMSD 0.92 Å
- 3KFJ chain A against the predicted model P62993: TM-score 0.96, RMSD 0.92 Å
Elsewhere
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